Occupational Asthma Reference
Occupational immediate-type asthma and rhinitis due to rhodium salts,
Am J Ind Med,
Keywords: new cause, germany, rhodium, electroplater, rhinitis, occupational asthma, case report, skin prick test, challenge, platinum
Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances.
A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. Quantitative skin prick tests (SPT) and bronchial challenge tests with a dosimeter protocol were performed with quadrupling doses of the sodium chloride salts of rhodium (Na3RhCl6) and platinum (Na2PtCl6).
The patient showed positive SPT reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt; the molar concentrations differed by a factor of 256 in SPT and a factor of 16 in bronchial challenges.
Rhodium salts should be considered as occupational immediate-type allergens.
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