Oasys and Occupational Asthma

This website contains information on Occupational Asthma and a free multi award winning computer program called OASYS, which is used to help diagnose Occupational Asthma from serial peak flow records. Oasys shows further information and downloads for the Oasys program. References is a searchable database of more than 5000 published papers in the field of occupational asthma. Causes shows some of the causes of occupational asthma. The Shield scheme reports some statistics for occupational asthma, mainly in the West midlands region, UK. BOHRF shows the evidence based occupational asthma guidelines for the UK. The interactive Case Histories are a learning resource for interested health professionals. There are also Medics, Specialists, Employers and Worker sections.

Latest News

Occupational asthma: Diacetyl associated with wide range of lung diseasess in popcorn flavourers Diacetyl associated with wide range of lung diseasess in popcorn flavourers 15 08 2018
Occupational asthma: Gene-environment interactions identified in cleaners and healthcare workers with occupational asthma. Gene-environment interactions identified in cleaners and healthcare workers with occupational asthma 01 08 2018
Occupational asthma: Biological monitoring in platinum refiners has very long half life Biological monitoring in platinum refiners has very long half life 04 06 2018
Occupational asthma: First cross-sectional study of 3D printers showing asthma, rhinitis and skin symptoms First cross-sectional study of 3D printers showing asthma, rhinitis and skin symptoms 04 06 2018
Occupational asthma: Oasys plots and challenge tests show concordant results Oasys plots and challenge tests show concordant results 19 05 2018

Latest Publications

Abstract Available for Occupational asthma from epoxy compounds. Suojalehto H, Sastre J, Merimaa E, Lindström I, Suuronen K. , Occupational asthma from epoxy compounds., J Allergy Clin Immunol Pract, 2018;:,10.1016/j.jaip.2018.07.023
Joaquin Sastre, Fundacion Jimenez Diaz, Madrid, an author of 'Occupational asthma from epoxy compounds.' Hille Suojalehto, Finnish Institute of Occupational Health, an author of 'Occupational asthma from epoxy compounds.' Irmeli Lindstrom, Finnish Institute of Occupational Health, an author of 'Occupational asthma from epoxy compounds.'

Abstract Available for Burden of respiratory abnormalities in microwave popcorn and flavouring manufacturing workers. Fechter-Leggett ED, White SK, Fedan KB, Cox-Ganser JM, Cummings KJ., Burden of respiratory abnormalities in microwave popcorn and flavouring manufacturing workers., Occup Environ Med, 2018;:,10.1136/oemed-2018-105150

Abstract Available for Asthmatic reactions after nasal allergen provocation. Baur X, Asthmatic reactions after nasal allergen provocation., Respiration, 1996;63:84-87,https://doi.org/10.1159/000196523
Xaver Baur, Institute of occupational medicine, Hamburg, an author of 'Asthmatic reactions after nasal allergen provocation.'

Go to "References" section.

Latest Forum Questions

Can acute formaldehyde exposure trigger sensitisation to another agent?
I carry our respiratory health surveillance for a poultry hatchery company. One of their workers was acutely exposed to ? formaldehyde in November 2016 enough to prompt an A&E attendance, and subsequently developed respiratory symptoms. Initially these were unrelated to work but at his kast surveillance he noted work related symptoms suggestive of OA. His FEV1 has not significantly declined since he started surveillance in 2011 and until 2017 he was symptom free. I have just got his serial peak flow results back and this is strongly suggestive of OA with an OASYS score of 3.4, PEF difference of 5.24%, ABC of 35.51 and positive (+6) timepoint analysis. It wold seem that he has developed occupational asthma sensitised to poultry dust. He has worked in the industry since 2011 as a maintenance engineer but has only recently developed problems, since his acute formaldehyde exposure. Could this be a trigger to his developing OA? Many thanks.
Occupational Asthma, Health Professional, 8/18/2018, 8/20/2018,

occupational asthma from chromium
Is it possible to become sensitised (respiratory) to the grindings of a chrome-containing prosthesis; or does the chrome need to be in the form of a hexavalent salt?
Occupational Asthma, Specialist, 8/1/2018, 8/1/2018,

Comments for the page titled: "Gene-environment interactions identified in cleaners and healthcare workers with occupational asthma."
Exposure alone does not account for susceptibility to develop occupational asthma, and gene-environment interactions are likely to be involved (as well as other factors such as smoking and any possible high-dose tolerance). Data from three large European cohorts: EGEA, SAPALDIA, and ECRHS used a candidate pathway-based strategy to identify 163 genes involved in response to oxidative stress and potentially related with exposures in cleaners and healthcare workers. Eight SNP by exposure interactions at five loci were found at p<0.005: PLA2G4A (rs932476, chromosome 1), near PLA2R1 (rs2667026, chromosome 2), near RELA (rs931127, rs7949980, chromosome 11), PRKD1 (rs1958980, rs11847351, rs1958987, chromosome 14), and PRKCA (rs6504453, chromosome 17). Results were consistent across the three studies and after accounting for smoking.
Page Comments, , 8/1/2018, 8/1/2018,

The Website

This website is run by the Oasys research group, part of the Midland Thoracic Society, UK. We are an independent group of clinicians and researchers, and run a clinical service for workers with occupational lung disease as part of the British National Health Service. We have developed the Oasys program to help ourselves and others in the diagnosis of occupational asthma. We have no specific funding, relying on research grants and the enthusiasm of our group. The website is written by Cedd Burge, who receives some funding from the group. The group meets about every 6 weeks on a Wednesday evening, as shown below.



As a casual user of this site (without logging in or registering) you can view all the information and use all the contact pages. Registered and logged in users (registering is free and we won't abuse your email) can download and use the Oasys program, ask and reply to questions in the forums, leave comments, add new references, add abstracts and full text links to existing references, answer questions in the case histories and provide evidence and suggest questions for future evidence based guidelines.

If you would like to be added to the list of known authors or collaborators then please register with the website (if you have not already done so) and then get in touch from the contact page. Once we have set the page up you will be able to edit it yourself and indicate which references you have written. Your picture will then be displayed along with each of these references. If you are already in these lists and would like to edit your page then please register with the website and then get in touch from the contact page.

Funding

Recent research grants / contracts have been received from the following.

The Oasys Team

Wasif Anees, Oasys Anees, Wasif (Oasys)
John Belcher, Oasys Belcher, John (Oasys)
Phil Bright, Oasys Bright, Phil (Oasys)
Cedd Burge, Oasys Burge, Cedd (Oasys)
Geraldine Burge, Birmingham Heartlands Hospital Burge, Geraldine (Birmingham Heartlands Hospital)
Sherwood Burge, Oasys Burge, Sherwood (Oasys)
Celia Catton, Oasys Catton, Celia (Oasys)
Vicki Drought, Oasys Drought, Vicki (Oasys)
Angela Evans, ARTP Evans, Angela (ARTP)
Paul Gannon, Dupont Gannon, Paul (Dupont)
Mike Hendy, Oasys Hendy, Mike (Oasys)
John Jackson, Jackson Hocking Limited, UK Jackson, John (Jackson Hocking Limited, UK)
Sarah Manney, Birmingham Heartlands Hospital Manney, Sarah (Birmingham Heartlands Hospital)
Jennifer McCoach (now Croft), Oasys McCoach (now Croft), Jennifer (Oasys)
Emmet McGrath, Oasys McGrath, Emmet (Oasys)
David Miedinger, Lucern, Basel and Montreal Miedinger, David (Lucern, Basel and Montreal)
Vicky Moore, Oasys Moore, Vicky (Oasys)
Darren Newton, Oasys Newton, Darren (Oasys)
Charles Pantin, Keele, UK Pantin, Charles (Keele, UK)
Edward Parkes, Birmingham Heartlands Hospital Parkes, Edward (Birmingham Heartlands Hospital)
Alastair Robertson, Selly Oak Hospital Robertson, Alastair (Selly Oak Hospital)
Arun Dev Vellore, Oasys Vellore, Arun Dev (Oasys)
Gareth Walters, Heartlands Walters, Gareth (Heartlands)

Collaborators

Irmeli Lindstrom, Finnish Institute of Occupational Health Lindstrom, Irmeli (Finnish Institute of Occupational Health)
Hille Suojalehto, Finnish Institute of Occupational Health Suojalehto, Hille (Finnish Institute of Occupational Health)
Xaver Baur, Institute of occupational medicine, Hamburg Baur, Xaver (Institute of occupational medicine, Hamburg)
Don Cockcroft, Saskatoon Cockcroft, Don (Saskatoon)
André Cartier, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Cartier, André (Hôpital de Sacré Coeur, Montreal, Quebec, Canada)
Paul Cullinan, Royal Brompton Hospital, London, UK Cullinan, Paul (Royal Brompton Hospital, London, UK)
Jennifer Hoyle, North Manchester General Hospital Hoyle, Jennifer (North Manchester General Hospital)
Giana Moscato, Fondazione Salvatore Maugeri, Pavia Moscato, Giana (Fondazione Salvatore Maugeri, Pavia)
Olivier Vandenplas, Universite Mont-Goginne, Yvoir Vandenplas, Olivier (Universite Mont-Goginne, Yvoir)
Cecile Svanes, University of Bergen, Norway Svanes, Cecile (University of Bergen, Norway)

Known Authors

Joaquin Sastre, Fundacion Jimenez Diaz, Madrid Sastre, Joaquin (Fundacion Jimenez Diaz, Madrid)
J Leuppi, Basel Leuppi, J (Basel)
Maria Jesus Cruz, Barcelona Cruz, Maria Jesus (Barcelona)
David Bernstein, Cincinatti Bernstein, David (Cincinatti)
Catherine Lemière, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Lemière, Catherine (Hôpital de Sacré Coeur, Montreal, Quebec, Canada)
Zana Lummus, Cincinatti Lummus, Zana (Cincinatti)
Xavier Munoz, Barcelona Munoz, Xavier (Barcelona)
Santiago Quirce, Madrid Quirce, Santiago (Madrid)
Susan Tarlo, Toronto Tarlo, Susan (Toronto)
Rolf Merget, Bochum Merget, Rolf (Bochum)

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