Oasys and Occupational Asthma

This website contains information on Occupational Asthma and a free multi award winning computer program called OASYS, which is used to help diagnose Occupational Asthma from serial peak flow records. Oasys shows further information and downloads for the Oasys program. References is a searchable database of more than 5000 published papers in the field of occupational asthma. Causes shows some of the causes of occupational asthma. The Shield scheme reports some statistics for occupational asthma, mainly in the West midlands region, UK. BOHRF shows the evidence based occupational asthma guidelines for the UK. The interactive Case Histories are a learning resource for interested health professionals. There are also Medics, Specialists, Employers and Worker sections.

Latest News

Occupational asthma: Occupational Asthma Course 2021 Occupational Asthma Course 2021 09 11 2021
Occupational asthma: Working as a cleaner pre-conception may increase the risk of asthma in their progeny Working as a cleaner pre-conception may increase the risk of asthma in their progeny 30 10 2021
Occupational asthma: Causes of occupational hypersensitivity pneumonitis Causes of occupational hypersensitivity pneumonitis 26 10 2021
Occupational asthma: How to complete your peak flow measurements How to complete your peak flow measurements 14 10 2021
Occupational asthma: Induction of innate immunity to Chitin may explain some allergy to invertebrates Induction of innate immunity to Chitin may explain some allergy to invertebrates 21 08 2021

Latest Publications

Abstract Available for Lung function assessment and its association with blood chromium in a chromate exposed population Zhang Y, Su Z, Hu G, Hong S, Long C, Zhang Q, Zheng P, Wang T, Yu S, Yuan F, Zhu X, Jia G, Lung function assessment and its association with blood chromium in a chromate exposed population, Science of The Total Environment, 2021;:151741,https://doi.org/10.1016/j.scitotenv.2021.151741

Abstract Available for Case reports of indium lung disease in Taiwan Tsao Y, Fan H, Luo JJ, Case reports of indium lung disease in Taiwan, Journal of the Formosan Medical Association, 2021;2:893-898,https://doi.org/10.1016/j.jfma.2020.08.009

Full Text Available for Health effects of exposure to chlorination by-products in swimming pools. Couto M, Bernard A, Delgado L, Drobnic F, Kurowski M, Moreira A, Rodrigues-Alves R, Rukhadze M, Seys S, Wiszniewska M, Quirce S, Health effects of exposure to chlorination by-products in swimming pools., Allergy, 2021;76:3257-3275,https://doi.org/10.1111/all.15014
Santiago Quirce, Madrid, an author of 'Health effects of exposure to chlorination by-products in swimming pools.'

Go to "References" section.

Latest Forum Questions

Comments for the paper: "Association between occupational exposure to irritant agents and a distinct asthma endotype in adults.", 2021, Occup Environ Med
This paper defines a respiratory irritant very broadly to include most low molecular weight sensitisers (isocyanates, epoxy resins, amines, acrylates), as well as some possible high molecular weight allergens (moulds, wood) which most would not regard primarily as irritants. The paper groups asthmatics into 3 endotypes 1. symptomaric adult onset treated asthma with poor lung function, neutrophilia and incresaed fluorescent oxygenation products (a measure of damage due to oxidative stress). This group had more exposure to the list of "irritants". When broken down by category the risk was bighest for biocides 2. Asthma with rhinitis and low IgE 3. Atopic childhood-onset astma and high IgE
Published Paper Comments, , 10/11/2021, 10/11/2021,

Comments for the paper: "Endotyping asthma related to three different work exposures", 2021, J Allergy Clin Immunol
This is a complicated study investigating molecular mechanisms of work-related asthma due to flour, isocyanates and stainless steel welding. The welders were the only group showing active inflammation from differentially expressed genes in nasal mucosal biopsies, but asymptomatic welders were not included in the controls. All three groups showed activation of genes associated with neutrophil migration and degranulation. The numbers are rather small for generating associations from these three very different agents that can cause indistinguishable clinical disease.
Published Paper Comments, , 8/18/2021, 8/18/2021,

Comments for the paper: "Endotyping asthma related to three different work exposures", 2021, J Allergy Clin Immunol
This is a complicated study investigating molecular mechanisms of work-related asthma due to flour, isocyanates and stainless steel welding. The welders were the only group showing active inflammation from differentially expressed genes in nasal mucosal biopsies, but asymptomatic welders were not included in the controls. All three groups showed activation of genes associated with neutrophil migration and degranulation. The numbers are rather small for generating associations from these three very different agents that can cause indistinguishable clinical disease.
Published Paper Comments, , 8/18/2021, 8/18/2021,

The Website

This website is run by the Oasys research group, part of the Midland Thoracic Society, UK. We are an independent group of clinicians and researchers, and run a clinical service for workers with occupational lung disease as part of the British National Health Service. We have developed the Oasys program to help ourselves and others in the diagnosis of occupational asthma. We have no specific funding, relying on research grants and the enthusiasm of our group. The website is written by Cedd Burge, who receives some funding from the group. The group meets every Friday evening after the occupational lung disease clinic, as shown below.



As a casual user of this site (without logging in or registering) you can view all the information and use all the contact pages. Registered and logged in users (registering is free and we won't abuse your email) can download and use the Oasys program, ask and reply to questions in the forums, leave comments, add new references, add abstracts and full text links to existing references, answer questions in the case histories and provide evidence and suggest questions for future evidence based guidelines.

If you would like to be added to the list of known authors or collaborators then please register with the website (if you have not already done so) and then get in touch from the contact page. Once we have set the page up you will be able to edit it yourself and indicate which references you have written. Your picture will then be displayed along with each of these references. If you are already in these lists and would like to edit your page then please register with the website and then get in touch from the contact page.

Funding

Recent research grants / contracts have been received from the following.

The Oasys Team

Wasif Anees, Oasys Anees, Wasif (Oasys)
John Belcher, Oasys Belcher, John (Oasys)
Phil Bright, Oasys Bright, Phil (Oasys)
Cedd Burge, Oasys Burge, Cedd (Oasys)
Geraldine Burge, Birmingham Heartlands Hospital Burge, Geraldine (Birmingham Heartlands Hospital)
Sherwood Burge, Oasys Burge, Sherwood (Oasys)
Celia Catton, Oasys Catton, Celia (Oasys)
Vicki Drought, Oasys Drought, Vicki (Oasys)
Angela Evans, ARTP Evans, Angela (ARTP)
Paul Gannon, Dupont Gannon, Paul (Dupont)
Mike Hendy, Oasys Hendy, Mike (Oasys)
Chris Huntley, University Hospitals Birmingham Huntley, Chris (University Hospitals Birmingham)
John Jackson, Jackson Hocking Limited, UK Jackson, John (Jackson Hocking Limited, UK)
Sarah Manney, Birmingham Heartlands Hospital Manney, Sarah (Birmingham Heartlands Hospital)
Jennifer McCoach (now Croft), Oasys McCoach (now Croft), Jennifer (Oasys)
Emmet McGrath, Oasys McGrath, Emmet (Oasys)
David Miedinger, Lucern, Basel and Montreal Miedinger, David (Lucern, Basel and Montreal)
Vicky Moore, Oasys Moore, Vicky (Oasys)
Darren Newton, Oasys Newton, Darren (Oasys)
Charles Pantin, Keele, UK Pantin, Charles (Keele, UK)
Edward Parkes, Birmingham Heartlands Hospital Parkes, Edward (Birmingham Heartlands Hospital)
Alastair Robertson, Selly Oak Hospital Robertson, Alastair (Selly Oak Hospital)
Arun Dev Vellore, Oasys Vellore, Arun Dev (Oasys)
Gareth Walters, Heartlands Walters, Gareth (Heartlands)

Collaborators

Vivi Schlunssen, Aarhus Schlunssen, Vivi (Aarhus)
Cecile Svanes, University of Bergen, Norway Svanes, Cecile (University of Bergen, Norway)
Kjell Toren, Sahlgrenska University Hospital. Goteborg Toren, Kjell (Sahlgrenska University Hospital. Goteborg)
Jan-Paul Zock, Municipal Institute of Medical Research, Barcelona, Spain Zock, Jan-Paul (Municipal Institute of Medical Research, Barcelona, Spain)
Steve Sadhra, Institute of Occupational and Environmental Health, Birmingham Sadhra, Steve (Institute of Occupational and Environmental Health, Birmingham)
Irmeli Lindstrom, Finnish Institute of Occupational Health Lindstrom, Irmeli (Finnish Institute of Occupational Health)
Hille Suojalehto, Finnish Institute of Occupational Health Suojalehto, Hille (Finnish Institute of Occupational Health)
Naesinee Chaiear, Khon Kaen University, Thailand Chaiear, Naesinee (Khon Kaen University, Thailand)
Ben Nemery, Leuven, Belgium Nemery, Ben (Leuven, Belgium)
Maritta Jaakkola, Oulu University Finland Jaakkola, Maritta (Oulu University Finland)

Known Authors

Santiago Quirce, Madrid Quirce, Santiago (Madrid)
Torben Sigsgaard, University of Aarhus Sigsgaard, Torben (University of Aarhus)
Orianne Dumas, Villejuif, France Dumas, Orianne (Villejuif, France)
Stephan Keirsbilck, IDEWE occupational Health Belgium Keirsbilck, Stephan (IDEWE occupational Health Belgium)
Jouni Jaakkola, Institute of Occupational and Environmental Medicine, Birmingham Jaakkola, Jouni (Institute of Occupational and Environmental Medicine, Birmingham)
Martin Seed, Manchester University Seed, Martin (Manchester University)
Xavier Munoz, Barcelona Munoz, Xavier (Barcelona)
T Rochat, Geneva Rochat, T (Geneva)
Oyvind Omland, Aahus Denmark Omland, Oyvind (Aahus Denmark)
Ilenia Folletti, Perugia Folletti, Ilenia (Perugia)

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