Oasys and Occupational Asthma

This website contains information on Occupational Asthma and a free multi award winning computer program called OASYS, which is used to help diagnose Occupational Asthma from serial peak flow records. Oasys shows further information and downloads for the Oasys program. References is a searchable database of more than 4,500 published papers in the field of occupational asthma. Causes shows some of the causes of occupational asthma. The Shield scheme reports some statistics for occupational asthma, mainly in the West midlands region, UK. BOHRF shows the evidence based occupational asthma guidelines for the UK. The interactive Case Histories are a learning resource for interested health professionals. There are also Medics, Specialists, Employers and Worker sections.

Latest News

Occupational asthma: Why do workers with the highest exposure to laboratory animals have less disease than those with intermediate exposure? Why do workers with the highest exposure to laboratory animals have less disease than those with intermediate exposure? 05 09 2014
Occupational asthma: Fatal lung disease in adults and children using humidifiers at home containing detergent biocides Fatal lung disease in adults and children using humidifiers at home containing detergent biocides 18 08 2014
Occupational asthma: Cobalt dissolved in metal-working fluid causes an ongoing outbreak of occupational asthma Cobalt dissolved in metal-working fluid causes an ongoing outbreak of occupational asthma 16 07 2014
Occupational asthma: job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death. job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death. 02 06 2014
Occupational asthma: When and how to perform specific challenge tests with occupational agents When and how to perform specific challenge tests with occupational agents 01 06 2014

Latest Publications

Abstract Available for Respiratory disease associated with occupational inhalation to hop (Humulus lupulus) during harvest and processing Reeb-Whitaker CK, Bonauto DK , Respiratory disease associated with occupational inhalation to hop (Humulus lupulus) during harvest and processing , Ann Allergy Asthma Immunol , 2014 ; : , http://dx.doi.org/10.1016/j.anai.2014.07.029

Abstract Available for Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE–allergen complex binding in laboratory animal workers Jones M, Jeal H, Schofield S, Harris JM, Shamji MH, Francis JN, Durham SR, Cullinan P , Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE–allergen complex binding in laboratory animal workers , Occup Environ Med , 2014 ; 71 : 619-623 , 10.1136/oemed-2014-102119
Paul Cullinan, Royal Brompton Hospital, London, UK, an author of 'Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE–allergen complex binding in laboratory animal workers' Meinir Jones, Royal Brompton Hospital, London, an author of 'Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE–allergen complex binding in laboratory animal workers' Jessica Harris, Royal Brompton Hospital, an author of 'Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE–allergen complex binding in laboratory animal workers'

Abstract Available for Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life Kellberger J, Peters-Weist AS, Heinrich S, Pfeiffer S, Vogelberg C, Roller D, Genuneit J, Weinmayr G, von Mutius E, Heumann C, Nowak D, Radon K , Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life , Eur Respir J , 2014 ; 44 : 657-665 , 10.1183/09031936.00153013
Dennis Nowak, Institute fur Arbeits, Munich, an author of 'Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life' Katja Radon, Ludwig Maximillian University, Munich, an author of 'Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life' Erica von Mutius, Munich, an author of 'Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life'

Go to "References" section.

Latest Forum Questions

Comments for the paper: "Positive alveolar responses to inhalation provocation tests: their validity and recognition", 1980, Thorax
two to nine hours and reached maximum intensities after between six and 20 hours of the start of exposure. In one subject with farmer's lung, symptoms began after about one hour, while in two avian reactors the onset of symptoms was delayed for 12-18 hours after the start of exposure. With both these avian reactors the maximum intensity of the symptoms experienced was not reached until the next day. All positive reactions were consequently of the "late" type, and all persisted for a minimum of several hours.
Published Paper Comments, , 05/09/2014, 05/09/2014,

Comments for the paper: "Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE–allergen complex binding in laboratory animal workers", 2014, Occup Environ Med
Results from a cross-sectional study of laboratory animal workers exposed to rats showed that IgG and IgG4 antibodies to rat urinary protein reduced specific IgE binding to B cells, perhaps explaining the U shaped dose-response curve seen in cross-sectional studies, where those with the highest exposures have relatively less disease.
Published Paper Comments, , 05/09/2014, 05/09/2014,

Comments for the paper: "Predictors of work-related sensitisation, allergic rhinitis and asthma in early work life", 2014, Eur Respir J
A slightly odd study, looking at predictors of sensitisation to occupational allergens to which most were not exposed. Allergens tested were a-amylase,Aspergillus, latex, Lepidoglyphus destructor-Lep d 1, mouse, rat,Tyrophagus, Rye flour. Predictors were non-occupational
Published Paper Comments, , 01/09/2014, 01/09/2014,

The Website

This website is run by the Oasys research group, part of the Midland Thoracic Society, UK. We are an independent group of clinicians and researchers, and run a clinical service for workers with occupational lung disease as part of the British National Health Service. We have developed the Oasys program to help ourselves and others in the diagnosis of occupational asthma. We have no specific funding, relying on research grants and the enthusiasm of our group. The website is written by Cedd Burge, who receives some funding from the group. The group meets about every 6 weeks on a Wednesday evening, as shown below.

Oasys Team

As a casual user of this site (without logging in or registering) you can view all the information and use all the contact pages. Registered and logged in users (registering is free and we won't abuse your email) can download and use the Oasys program, ask and reply to questions in the forums, leave comments, add new references, add abstracts and full text links to existing references, answer questions in the case histories and provide evidence and suggest questions for future evidence based guidelines.

If you would like to be added to the list of known authors or collaborators then please register with the website (if you have not already done so) and then get in touch from the contact page. Once we have set the page up you will be able to edit it yourself and indicate which references you have written. Your picture will then be displayed along with each of these references. If you are already in these lists and would like to edit your page then please register with the website and then get in touch from the contact page.

Funding

Recent research grants / contracts have been received from the following.

The Oasys Team

Wasif Anees, Oasys Anees, Wasif (Oasys)
John Belcher, Oasys Belcher, John (Oasys)
Phil Bright, Oasys Bright, Phil (Oasys)
Cedd Burge, Oasys Burge, Cedd (Oasys)
Sherwood Burge, Oasys Burge, Sherwood (Oasys)
Celia Catton, Oasys Catton, Celia (Oasys)
Vicki Drought, Oasys Drought, Vicki (Oasys)
Angela Evans, ARTP Evans, Angela (ARTP)
Paul Gannon, Dupont Gannon, Paul (Dupont)
John Jackson, Jackson Hocking Limited, UK Jackson, John (Jackson Hocking Limited, UK)
Sarah Manney, Birmingham Heartlands Hospital Manney, Sarah (Birmingham Heartlands Hospital)
Jennifer McCoach (now Croft), Oasys McCoach (now Croft), Jennifer (Oasys)
Emmet McGrath, Oasys McGrath, Emmet (Oasys)
David Miedinger, Lucern, Basel and Montreal Miedinger, David (Lucern, Basel and Montreal)
Vicky Moore, Oasys Moore, Vicky (Oasys)
Darren Newton, Oasys Newton, Darren (Oasys)
Charles Pantin, Keele, UK Pantin, Charles (Keele, UK)
Edward Parkes, Birmingham Heartlands Hospital Parkes, Edward (Birmingham Heartlands Hospital)
Alastair Robertson, Selly Oak Hospital Robertson, Alastair (Selly Oak Hospital)
Arun Dev Vellore, Oasys Vellore, Arun Dev (Oasys)
Gareth Walters, Heartlands Walters, Gareth (Heartlands)

Collaborators

Carl Reynolds, Royal Brompton Hospital Reynolds, Carl (Royal Brompton Hospital)
Paul Cullinan, Royal Brompton Hospital, London, UK Cullinan, Paul (Royal Brompton Hospital, London, UK)
Meinir Jones, Royal Brompton Hospital, London Jones, Meinir (Royal Brompton Hospital, London)
Katja Radon, Ludwig Maximillian University, Munich Radon, Katja (Ludwig Maximillian University, Munich)
Dennis Nowak, Institute fur Arbeits, Munich Nowak, Dennis (Institute fur Arbeits, Munich)
Kjell Toren, Sahlgrenska University Hospital. Goteborg Toren, Kjell (Sahlgrenska University Hospital. Goteborg)
Giana Moscato, Fondazione Salvatore Maugeri, Pavia Moscato, Giana (Fondazione Salvatore Maugeri, Pavia)
Ben Nemery, Leuven, Belgium Nemery, Ben (Leuven, Belgium)
Vivi Schlunssen, Aarhus Schlunssen, Vivi (Aarhus)
Olivier Vandenplas, Universite Mont-Goginne, Yvoir Vandenplas, Olivier (Universite Mont-Goginne, Yvoir)

Known Authors

Orianne Dumas, Villejuif, France Dumas, Orianne (Villejuif, France)
Jessica Harris, Royal Brompton Hospital Harris, Jessica (Royal Brompton Hospital)
Erica von Mutius, Munich von Mutius, Erica (Munich)
Santiago Quirce, Madrid Quirce, Santiago (Madrid)
Joaquin Sastre, Fundacion Jimenez Diaz, Madrid Sastre, Joaquin (Fundacion Jimenez Diaz, Madrid)
Torben Sigsgaard, University of Aarhus Sigsgaard, Torben (University of Aarhus)
Susan Tarlo, Toronto Tarlo, Susan (Toronto)
Andrea Siracusa, Perugia Siracusa, Andrea (Perugia)
Martin Ruegger, Ruegger, Martin ()
Martin Ruegger, Luzern Ruegger, Martin (Luzern)

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