Occupational Asthma Reference
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Quirce S, Pelta R, Sastre J,
Occupational asthma due to piperazine citrate.,
J Inv Allergod Clin Immunol,
2006;16:138-139,
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Keywords: challenge, piperazine, spain, case report, chemical processor, rhinitis, asthma, skin prick test, challenge, NSBR
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Abstract
BACKGROUND: Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism.
METHODS: We report on a 42-year-old woman, a process operator in a chemical factory, who developed work-related symptoms of rhinitis and asthma upon exposure to piperazine citrate. She remained symptom free during holidays and days off work.
RESULTS: Skin prick test with piperazine citrate was positive. Specific inhalation challenge with piperazine citrate at a concentration of 5 mg/m3 for 30 minutes elicited an isolated late asthmatic response. Airway hyperresponsiveness to methacholine significantly increased 3 hours after the piperazine challenge, preceding the late asthmatic response.
CONCLUSION: This patient had developed occupational asthma caused by piperazine, as confirmed by the specific inhalation challenge test, possibly due to an immunological mechanism.
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