Occupational Asthma Reference
Occupational asthma caused by FD&C blue dye no. 2,
Allergy Asthma Proc,
Keywords: USA, indigotine, dye, case report, ch, food, nc, Male, who, cough, non-occupational, IgE, IgA, IgM, IgG, ets, alveolitis, X, FEV1, asthma
We report the case of a 55-year-old male who experienced cough, dyspnea, wheezing, and nasal congestion immediately upon exposure to FD&C Blue Dye No. 2 (Indigotine) at work. The patient had worked for 10 years mixing and grinding powdered synthetic red, yellow, and blue dyes for use in foods; symptoms had occurred for 2 years and only with exposure to Indigotine (C16H8N2Na2O8S2), a free flowing blue powder. Prick testing to Indigotine (20 mg/mL) was negative. ELISA failed to detect specific IgE, IgA, IgM, or IgG to Indigotine-HSA conjugates. Bronchial challenge was done according to the method of Pepys et al. beginning with 4 x 10(-4) lactose dilution of Indigotine powder. After 5 minutes of exposure to 4 gm Indigotine/100 gm lactose, the patient developed dyspnea and audible wheezing. At 20 minutes postexposure, there was a 20% decline in FEV1 from prechallenge baseline; no late phase response was observed. A second bronchial challenge with sodium sulfate, the major nondye product additive was negative. To our knowledge, this is the first documented case of occupational asthma due to FD&C Blue Dye No. 2. The pathogenesis is uncertain but does not appear to be IgE mediated
Full text of this reference not available
Please Log In or Register to add the full text to this reference
There are no associations for this paper.
Please Log In or Register to put forward this reference as evidence to a question.
Please sign in or register to add your thoughts.