Occupational Asthma Reference

O'Brien IM, NewmanTaylor AJ, Burge PS, Harries MG, Fawcett IW, Pepys J, Toluene di-isocyanate-induced asthma. II. Inhalation challenge tests and bronchial reactivity studies, Clin Allergy, 1979;9:7-15,

Keywords: oa, asthma, TDI, br, ch, HDI, MDI

Known Authors

Sherwood Burge, Oasys Sherwood Burge

Jack Pepys, Royal Brompton Hospital Jack Pepys

Mark Harries, Brompton Hospital and Northwick Park Mark Harries

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.


In sixty-three workers exposed to toluene di-isocyanate (TDI), no overall differences in bronchial reactivity to histamine inhalation and to exercise testing were found between the total groups of positive and negative TDI reactors to provocation tests. A subgroup of TDI highly sensitive subjects reacting to very low concentrations (less than or equal to 0.001 p.p.m.) were more sensitive to both histamine and exercise than the group who were less sensitive to TDI, and who reacted to higher concentrations (0.002--0.02 p.p.m.) than the group of non-reactors. There were, however, in the last group a number of subjects with high degrees of histamine reactivity who did not react to the TDI. These findings suggest that, on the one hand, the asthmatic reactions to TDI cannot be attributed solely to non-specific mechanisms and, on the other, that in subjects with high degrees of specific sensitivity non-specific mechanisms may also be playing a part

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Associated Questions

There are no associations for this paper.

Please Log In or Register to put forward this reference as evidence to a question.

Bohrf Occupational Asthma Guidelines

This reference has been analysed as part of the BOHRF occupational asthma guidelines. Please click to view the Bohrf occupational asthma guideline data for this reference.


Please sign in or register to add your thoughts.

Oasys and occupational asthma smoke logo