Occupational Asthma Reference

Czuppon AB, Kaplan V, Speich R, Baur X, Acute autoimmune response in a case of pyromellitic acid dianhydride-induced hemorrhagic alveolitis, Allergy, 1994;49:337-341,

Keywords: alveolitis, Germany, epoxy resin, IgG, anhydride, IgE, pyromelliticaciddianhydride, pulmonary haemorrhage

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Xaver Baur, Institute of occupational medicine, Hamburg Xaver Baur

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A 17-year-old man was occupationally exposed to pyromellitic acid dianhydride dust during the production of epoxy resin in a chemical factory. He was clinically diagnosed as having acute hemorrhagic alveolitis associated with anemia. The serologic analysis revealed a high concentration of IgG antibodies against pyromellitic acid dianhydride-treated human serum albumin (PMDA-HSA). Immunoblotting with PMDA-treated human serum as antigen and the patient's serum as the first antibody showed that additional PMDA-modified serum proteins other than HSA were recognized by the patient's IgG antibodies in the higher mol. mass range (> 67 kDa). No specific IgG could be detected against other anhydride conjugates (maleic acid, MA; phthalic acid, PA) with the exception of a reaction with the trimellitic acid anhydride-conjugated HSA (TMA-HSA). No specific IgE antibodies could be detected against any of the above mentioned antigens, but immunoblotting of the patient's serum indicated IgG4-type autoantibodies against in vitro PMDA-treated Ig molecules of normal serum proteins

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