Occupational Asthma Reference

Tse KS, Johnson A, Chan H, ChanYeung M, A study of serum antibody activity in workers with occupational exposure to diphenylmethane diisocyanate, Allergy, 1985;40:314-320,

Keywords: oa, prevalence, foundry, MDI, IgE, IgG, ep, cross sectional, as

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Moira Chan-Yeung, University of Hong Kong Moira Chan-Yeung

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The prevalence of sensitization was studied in a group of 76 foundry workers with occupational exposure to diphenylmethane diisocyanate (MDI). Ten workers had clinical evidence of asthma, 40 had non-asthmatic respiratory symptoms, and 26 were asymptomatic. Specific IgE antibodies to MDI were found in two workers (2.6%) and specific IgG antibodies, in five workers (6.6%). The prevalence of IgE and IgG antibodies was higher in the 10 subjects with asthma than in the non-asthmatic group. The prevalence of anti-paratolyl-monoisocyanate antibodies was not significantly different from that of anti-MDI antibodies, and both haptenic determinants displayed a high degree of cross-reactivity in the RAST inhibition test. The role of humoral immunological mechanisms in MDI-induced asthma is unclear in view of the rather low prevalence of these serum antibodies in this group of workers

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