Occupational Asthma Reference

Rylander R, Donham KJ, Hjort C, Brouwer R, Heederik D, Effects of exposure to dust in swine confinement buildings--a working group report, Scand J Work Environ Health, 1989;15:309-312,

Keywords: ob, pig, farmer, review

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Dick Heederik, Institute of Risk Assessment Sciences, Utrecht Dick Heederik

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Pulmonary and other symptoms among workers in swine confinement buildings were evaluated by an international working group. In several studies in five different countries a total of about 2000 workers has been studied in clinical and epidemiologic investigations. Symptoms indicative of acute and chronic airway inflammation were widespread, as were systemic reactions of organic dust toxic syndrome. The base-line, and across workshift, pulmonary function changes were moderate. There was no evidence that antigen-antibody reactions are important in the pathogenesis. Longitudinal studies are recommended to establish the relationship between acute and chronic symptoms and end stage disease

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