Occupational Asthma Reference

Baur X, Asthmatic reactions after nasal allergen provocation., Respiration, 1996;63:84-87,https://doi.org/10.1159/000196523

Keywords: pyromellitic dianhydride, nasal challenge, oa,

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Xaver Baur, Institute of occupational medicine, Hamburg Xaver Baur

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Three bronchoconstrictive responses associated with acute rhinitis and occurring in two patients were observed among 400 nasal allergen challenges. Causative substances were birch pollen, Dermatophagoides pteronyssinus and HSA-conjugated pyromellitic dianhydride. Both subjects showed bronchial hyperreactivity and immediate-type sensitization to these allergens. It is concluded that bronchoobstruction nearly occurs in nasal allergen challenges. The underline pathophysiological mechanism remains unclear.

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