Occupational Asthma Reference

Tarlo SM, Malo J, de Blay F, Moual NL, Henneberger P, Heederik D, Raulf M, Carlsten C, and Cartier A,, An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace, Annals ATS, 2017;:,https://doi.org/10.1513/AnnalsATS.201706-508ST

Keywords: Pepys, OA,

Known Authors

Don Milton, Harvard Don Milton

Paul Cullinan, Royal Brompton Hospital, London, UK Paul Cullinan

David Baldwin, Nottingham, UK David Baldwin

Tony Pickering, Wythenshawe Hospital, Manchester, UK Tony Pickering

David Blainey, Essex, UK David Blainey

Ian Pavord, Leicester, UK Ian Pavord

André Cartier, Hôpital de Sacré Coeur, Montreal, Quebec, Canada André Cartier

Ben Nemery, Leuven, Belgium Ben Nemery

Paul Henneberger, NIOSH, Morgantown, USA Paul Henneberger

Paul Enright, NIOSH, Morgantown, USA Paul Enright

Olivier Vandenplas, Universite Mont-Goginne, Yvoir Olivier Vandenplas

Joanne Harris-Roberts (nee Elms), HSL, Buxton, UK Joanne Harris-Roberts (nee Elms)

Josep Antó, Barcelona, Catalonia, Spain Josep Antó

Andrew Curran, HSL, Sheffield, UK Andrew Curran

John Jackson, Jackson Hocking Limited, UK John Jackson

David Fishwick, Royal Hallamshire Hospital, Sheffield, UK David Fishwick

Chris Stenton, Newcastle upon Tyne, UK Chris Stenton

Sherwood Burge, Oasys Sherwood Burge

Charles Pantin, Keele, UK Charles Pantin

Wasif Anees, Oasys Wasif Anees

Paul Gannon, Dupont Paul Gannon

Phil Bright, Oasys Phil Bright

Vicki Drought, Oasys Vicki Drought

Vicky Moore, Oasys Vicky Moore

Jennifer McCoach (now Croft), Oasys Jennifer McCoach (now Croft)

Celia Catton, Oasys Celia Catton

John Belcher, Oasys John Belcher

Cedd Burge, Oasys Cedd Burge

Darren Newton, Oasys Darren Newton

Johny Kongerud, Rikshospitalet, Oslo University, Norway Johny Kongerud

V Soyseth, Hydro Aluminium Aardal, Norway V Soyseth

Somkiat Siriruttanapruk, Ministry of Public Health, Thailand Somkiat Siriruttanapruk

Alastair Robertson, Selly Oak Hospital Alastair Robertson

Arun Dev Vellore, Oasys Arun Dev Vellore

Roger Rawbone, Retired - ex Health and Safety Executive Roger Rawbone

Lisa Bradshaw, Health and Safety Laboratories Lisa Bradshaw

Nerys Williams, Department of Work and Pensions Nerys Williams

Jack Pepys, Royal Brompton Hospital Jack Pepys

Maritta Jaakkola, Oulu University Finland Maritta Jaakkola

Jon Ayres, University of Birmingham Jon Ayres

John Cotes, Newcastle upon Tyne University John Cotes

Frederic de Blay, Hopital Universitaires de Strasbourg Frederic de Blay

Dick Heederik, Institute of Risk Assessment Sciences, Utrecht Dick Heederik

Joaquin Sastre, Fundacion Jimenez Diaz, Madrid Joaquin Sastre

Dennis Nowak, Institute fur Arbeits, Munich Dennis Nowak

Torben Sigsgaard, University of Aarhus Torben Sigsgaard

Warren Perks, Shrewsbury Hospital Warren Perks

Jack Barker, Kings College Hospital, London Jack Barker

David Weir, North Manchester Hospital David Weir

Leo Fabbri, University of Moderna and Reggio Emilia Leo Fabbri

Steve O'Hickey, Worcester Hospital Steve O'Hickey

Anne Burge, University Hospital Birmingham Occupational Health Anne Burge

Eva Hnizdo, NIOSH Eva Hnizdo

Moira Chan-Yeung, University of Hong Kong Moira Chan-Yeung

Stuart Brooks, University of South Florida Stuart Brooks

Peter Burney, Kings College, London Peter Burney

Fabio Di Stefano, Ospedale G.Bernabeo, Ortona Fabio Di Stefano

Jouni Jaakkola, Institute of Occupational and Environmental Medicine, Birmingham Jouni Jaakkola

Chris Brightling, Leicester University, Glenfield Hospital Chris Brightling

Tor Aasen, Haukeland University Hospital, Bergen Tor Aasen

Xaver Baur, Institute of occupational medicine, Hamburg Xaver Baur

Piero Maestrelli, Padova University, Italy Piero Maestrelli

Henrik Nordman, Finnsh Institute of Occupational Health Henrik Nordman

Pierluigi Paggiaro, Ospedale Cisanello, Pisa, Italy Pierluigi Paggiaro

Gabrielle Pauli, University of Strasbourg Gabrielle Pauli

Kay Kreiss, NIOSH, Morgantown USA Kay Kreiss

Bill Beckett, University of Rochester, NY Bill Beckett

Tettu Harju, Oulu University, Finland Tettu Harju

Jeroen Douwes, Massey University, Wellington, NZ Jeroen Douwes

Kjell Toren, Sahlgrenska University Hospital. Goteborg Kjell Toren

Carrie Redlich, Yale University, Newhaven Connecticut Carrie Redlich

Pawel Gorski, University of Lodz, Poland Pawel Gorski

Anna Rask-Andersen, Uppsala University Anna Rask-Andersen

Holger Dressel, Institute of Occupational and Environmental Medicine, Munich Holger Dressel

Jasminka Godnic-Cvar, Vienna Jasminka Godnic-Cvar

Joerg Reichert, Networm Joerg Reichert

George Praml, Institute of Occupational and Environmental Medicine, Munich George Praml

Raymond Agius, Centre for Occupational and Environmental Health, Manchester University Raymond Agius

Andy Slovak, Centre for Occupational and Environmental Health, Manchester University Andy Slovak

David Coggon, Southampton University David Coggon

John Harrison, Hammersmith Hospital, London John Harrison

Bill Tunnicliffe, University Hospital Birmingham Bill Tunnicliffe

Wendy Robertson, Public Health, Warwick University Wendy Robertson

Naesinee Chaiear, Khon Kaen University, Thailand Naesinee Chaiear

Tony Newman Taylor, Royal Brompton Hospital, London Tony Newman Taylor

Keith Palmer, Environmental Epidemiology Unit, Southampton University, UK Keith Palmer

Mark Britton, Ashford and St Peters Hospital, UK Mark Britton

Paul Nicholson, Procter And Gamble Occupational Health Paul Nicholson

Tar Ching Aw, Kent University, England Tar Ching Aw

BM Wright, Department of Bioengineering. Clinical Research Centre. Harrow, Middlesex BM Wright

Chris Warburton, Liverpool Chris Warburton

Jennifer Hoyle, North Manchester General Hospital Jennifer Hoyle

David Hendrick, Newcastle-upon-Tyne David Hendrick

Chris Barber, Health and Safety Laboratories, Buxton Chris Barber

Angela Fletcher, North West Lung Centre, Manchester Angela Fletcher

Ronald Lane, Manchester University Ronald Lane

Martin Hetzel, Bristol Royal Infirmary Martin Hetzel

Dick Orie, Groningen University Dick Orie

David Bryant, Sydney David Bryant

Michael Flindt, Manchester Michael Flindt

Martin Seed, Manchester University Martin Seed

Roseanne McNamee, Manchester University COEH Roseanne McNamee

Ian Gregg, Southampton University Ian Gregg

Kate Venables, Oxford University Kate Venables

Mandy Francis, Health and Safety Laboratories Mandy Francis

Jean-Luc Malo, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Jean-Luc Malo

Jeremy Beach, University of Alberta Jeremy Beach

Margaret Becklake, McGill University Margaret Becklake

David Bernstein, Cincinatti David Bernstein

Leonard Bernstein, Cincinatti Leonard Bernstein

Chris Carlsten, Seattle Chris Carlsten

Maria Jesus Cruz, Barcelona Maria Jesus Cruz

Helene Favreau, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Helene Favreau

Denise Gautrin, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Denise Gautrin

Deborah Hellyer, Windsor University, Ontario Deborah Hellyer

Linn Holness, Toronto University Linn Holness

Mohammed Jeebhay, Cape Town Mohammed Jeebhay

Meinir Jones, Royal Brompton Hospital, London Meinir Jones

Maryann Joseph, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Maryann Joseph

Francine Kauffmann, Inserm, Paris Francine Kauffmann

Susan Kennedy, Vancouver Susan Kennedy

Manon Labrecque, Hôpital de Sacre Coeur, Montreal, Quebec, Canada Manon Labrecque

Ute Latza, University of Apllied Sciences, Berlin Ute Latza

Garry Liss, Toronto Garry Liss

Catherine Lemière, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Catherine Lemière

Kim Lavoie, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Kim Lavoie

Bertrand Lefort, Bertrand Lefort

Zana Lummus, Cincinatti Zana Lummus

Karim Maghni, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Karim Maghni

Christina Mapp, Padova University Christina Mapp

Rolf Merget, Bochum Rolf Merget

Giana Moscato, Fondazione Salvatore Maugeri, Pavia Giana Moscato

Xavier Munoz, Barcelona Xavier Munoz

Jarim Pacheko, Denver Jarim Pacheko

Hae-Sim Park, Korea Hae-Sim Park

Santiago Quirce, Madrid Santiago Quirce

Jean-Phillipe Rioux, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Jean-Phillipe Rioux

Andrea Siracusa, Perugia Andrea Siracusa

Mark Swanson, Mark Swanson

Susan Tarlo, Toronto Susan Tarlo

Eric Bateman, Cape Town University Eric Bateman

Mark Levy, London GP Mark Levy

Raja Abboud, Vancouver Raja Abboud

Katja Radon, Ludwig Maximillian University, Munich Katja Radon

Bill Glass, Christchurch, New Zealand Bill Glass

Ed Robinson, Health and Safety Laboratories, Buxton, UK Ed Robinson

Paul Dawkins, University Hospital Birmingham Paul Dawkins

Jorgen Vestbo, Wythenshawe Hospital, Manchester Jorgen Vestbo

Paul Blanc, University of California San Francisco Paul Blanc

Dewi Davies, Nottingham Dewi Davies

Sean Jones, Birmingham Heartlands Hospital Sean Jones

Margaret Turner-Warwick, Royal Brompton Hospital Margaret Turner-Warwick

N Fujimura, Kyoto N Fujimura

Rob Niven, Wythenshawe Hospital, Manchester Rob Niven

Robert Cowie, University of Calgary Robert Cowie

Akwilina Kayumba, Department of Physiology, Muhimbili University,  Dar es Salaam, Tanzania Akwilina Kayumba

Jan-Paul Zock, Municipal Institute of Medical Research, Barcelona, Spain Jan-Paul Zock

Olga Vasilyeva, Pulmonary Research Institute, Moscow, Russia Olga Vasilyeva

Bert Brunekreef, Utrecht University, Netherlands Bert Brunekreef

Luiz Fernando F Silva, University of Sao Paulo, Brazil Luiz Fernando F Silva

Philippe Camus, Hôpital Le Bocage, Dijon, France Philippe Camus

Anna Góra, Institute of Agricultural Medicine, Lublin, Poland Anna Góra

Tim Clark, Royal Brompton Hospital Tim Clark

Dirkje Postma, Groningen University Dirkje Postma

Frits van Rooy, Utrecht University Frits van Rooy

Lidwien Smit, Utrecht University Lidwien Smit

Julia Smedley, Southampton University Hospital Julia Smedley

Dil Sen, Health and Safety Executive, UK Dil Sen

Mandy Henson, HSL, Buxton Mandy Henson

Sarah Manney, Birmingham Heartlands Hospital Sarah Manney

Angela Evans, ARTP Angela Evans

Angela Jones, Royal Brompton Hospital Angela Jones

Trevor Smith, Cheshire Trevor Smith

Malcomb Harrington, Institute of Occupational and Environmental Medicine, Birmingham Malcomb Harrington

Tony Seaton, Formerley Professor of Occupational and Environmental Medicine, Aberdeen Tony Seaton

Grant McMillan, Instute of Military Medicine, Birmingham Grant McMillan

Martin Miller, Selly Oak Hospital, Birmingham Martin Miller

Annemarie Money, Manchester University Annemarie Money

Marcin Golec, Institute of Agricultural Medicine, Lublin, Poland Marcin Golec

Rahul Mukherjee, Milton Keynes Hospital, UK Rahul Mukherjee

Neeraj Gupta, Maulana Azad Medical College, Delhi Neeraj Gupta

James Gaddie, Aberdeen James Gaddie

Charles McSharry, Western Infirmary, Glasgow Charles McSharry

Tony Davison, Southend Hospital, UK Tony Davison

John Miles, North Manchester John Miles

Nawar Bakerly, Birmingham Heartlands Hospital Nawar Bakerly

Fred Bio, University Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Fred Bio

Ronald Dahl, Aarhus University Ronald Dahl

David Honeybourne, Birmngham Heartlands Hospital David Honeybourne

John Reynolds, Birmingham Heartlands Hospital John Reynolds

Timo Hannu, Finnish Institute of Occupational Health Timo Hannu

Rich Heinink, West Midlands Respiratory Trainee Rich Heinink

Shyam Madathil, West Midlands Deanery Shyam Madathil

Richard Beasley, Wellington, New Zealand Richard Beasley

Eduard Monso, Badalona, Spain Eduard Monso

Martin Ruegger, Martin Ruegger

Oyvind Omland, Aahus Denmark Oyvind Omland

Ferran Morell, Vall d'Hebron Hospital, Barcelona Ferran Morell

Roser Costa, Barcelona (now moved) Roser Costa

Jordi Delclos, Texas University, Houston Jordi Delclos

Isabel Urrutia, Hospital de Galdakao, Bizkaia Isabel Urrutia

Gerald Langman, Birmingham Heartlands Hospital Gerald Langman

Allan Gibbs, Llandoch Hospital, Wales Allan Gibbs

Bryan Corrin, Royal Brompton Hospital Bryan Corrin

Paul de Vuyst, Erasme Hospital, Brussels Paul de Vuyst

Brita Stenius-Aaniala, Helsinki Brita Stenius-Aaniala

Jonathen Brostoff, Middlesex Hospital, London Jonathen Brostoff

Tony Frew, Brighton Tony Frew

Erica von Mutius, Munich Erica von Mutius

Maurice Lessof, Guys Hospital, London Maurice Lessof

Bill Cookson, Oxford Bill Cookson

Barry Kay, Royal Brompton Hospital Barry Kay

Steven Holgate, Southampton University Steven Holgate

Freddy Hargreave, McMaster University, Hamilton Freddy Hargreave

Bill Frankland, London; St Mays and Guys Hospitals (mainly) Bill Frankland

Andrew Wardlaw, Leicester University Andrew Wardlaw

Ahmed Arif, University of North Carolina Ahmed Arif

Loren Tapp, NIOSH Cincinatti Loren Tapp

Gareth Evans, HSL, Buxton Gareth Evans

Melanie Carder, COEH Manchester Melanie Carder

Catherine Boyle, Health and Safety Executive, UK Catherine Boyle

Jean Bourbeau, McGill University Montreal Jean Bourbeau

N Kunzli, Barcelona N Kunzli

J Leuppi, Basel J Leuppi

Martin Ruegger, Luzern Martin Ruegger

David Miedinger, Lucern, Basel and Montreal David Miedinger

Brigitta Danuser, Switzerland Brigitta Danuser

T Rochat, Geneva T Rochat

Peter Reid, Edinburgh Western General Hospital Peter Reid

Femi Adewole, Nigeria Femi Adewole

Robert McCallum, Newcastle University Robert McCallum

Prof Shashikant Karandikar, Chest Research Foundation (Pune, India) Prof Shashikant Karandikar

Roger Altounyan, Fisons Pharmacuticals Roger Altounyan

Dan Park, Birmingham Heartlands Hospital Dan Park

Jessica Harris, Royal Brompton Hospital Jessica Harris

Vivi Schlunssen, Aarhus Vivi Schlunssen

Gunter Ott, Innsbruck Gunter Ott

Svetlana Sergejeva, North Esonian Medival Centre, Tallinn Svetlana Sergejeva

Kjell Larsson, Karolinska Institute of Environmental Medicine Kjell Larsson

Hille Suojalehto, Finnish Institute of Occupational Health Hille Suojalehto

Irmeli Lindstrom, Finnish Institute of Occupational Health Irmeli Lindstrom

Jonas Brisman, Sahlgrenska Hospital, Gothenburg Jonas Brisman

Clare Burton, Sheffield University and HSL Buxton Clare Burton

Lee Newman, Colorado University Lee Newman

Rosemary Tee, Royal Brompton Hospital Rosemary Tee

Bob Murdoch, Brompton Hospital Bob Murdoch

Ian Coutts, Brompton Hospital and Cornwall Ian Coutts

Joan Longbottom, Brompton Hospital Joan Longbottom

Mark Harries, Brompton Hospital and Northwick Park Mark Harries

Oliver Cromwell, Brompton Hospital Oliver Cromwell

Peri Meram Arbak, Duzce University, Turkey Peri Meram Arbak

Ilenia Folletti, Perugia Ilenia Folletti

Heberto Ghezzo, Montreal Heberto Ghezzo

Ryan Hoy, Melbourne Ryan Hoy

Karin Pacheco, Denver Karin Pacheco

Jolanta Walusiak, Lodz Jolanta Walusiak

Luca Perfetti, Fondazione Salvatore Maugeri, Pavia Luca Perfetti

David Prezant, Albert Einstein College, New York David Prezant

Steve Sadra, Institute of Occupational and Environmental Health, Birmingham Steve Sadra

Len Levy, Institute of Occupational and Environmental Health, Birmingham Len Levy

Ian Calvert, Institute of Occupational and Environmental Health, Birmingham Ian Calvert

Craig Jackson, Institute of Occupational and Environmental Health, Birmingham, UK Craig Jackson

Eva Andersson, Eva Andersson

Jesper Baelum, Jesper Baelum

Don Cockcroft, Saskatoon Don Cockcroft

Jonas Eriksson, Gothenberg Jonas Eriksson

Susana Gomez-Olles, Barcelona Susana Gomez-Olles

JH Jacobs, Utrecht JH Jacobs

Dan Norback, Dan Norback

R Sepulveda, Santiago, Chile R Sepulveda

Peter S Thorne, Iowa Peter S Thorne

Giovani Viegi, Pisa Giovani Viegi

Bernard Higgins, Newcastle-on-Tyne Bernard Higgins

Brian Davies, Llandoch Hospital, Cardiff Brian Davies

John Moore-Gillon, St Bartholomews Hospital, London John Moore-Gillon

Richard Barraclough, Manchester Richard Barraclough

Nicola Cherry, University of Alberta, Edmonton, Canada Nicola Cherry

Emmet McGrath, Oasys Emmet McGrath

Tim Meijster, Tim Meijster

Peter Lange, Copenhagen, Denmark Peter Lange

David Hansell, Royal Brompton Hospital, London David Hansell

Bernardino Ramazzini, Universities of Moderna and Padua Bernardino Ramazzini

David Bolds, Boston Hospital, UK David Bolds

Alexandra Preisser, Hamburg Alexandra Preisser

Bamidele Adeniyi, Federal Medical Centre, Owo, Nigeria Bamidele Adeniyi

Edward Parkes, Birmingham Heartlands Hospital Edward Parkes

Howard J Mason, Health and Safety Laboratories, Buxton, UK Howard J Mason

Gareth Walters, Heartlands Gareth Walters

Jacques Pralong, Sacre Coeur, Montreal Jacques Pralong

Vincent Bonneterre, Occupational diseases centre / Grenoble Joseph Fourier University / RNV3P Vincent Bonneterre

Julie Cannon, Royal Brompton Hospital London Julie Cannon

Joanna Szram, Royal Brompton Hospital Joanna Szram

Jo Morley, Leicester Jo Morley

Cecile Svanes, University of Bergen, Norway Cecile Svanes

Jorunn Kirkeleit, University of Bergen, Norway Jorunn Kirkeleit

Monika Raulf-Heimsoth, Bochum Monika Raulf-Heimsoth

Alice Hamilton, Harvard Alice Hamilton

Susan Turner, Centre for Occupational and Environmental Medicine Manchester Susan Turner

Michael Abramson, Monash University, Melbourne, Australia Michael Abramson

Jean-Claude Pairon, Centre Hospitalier Intercommunal de Créteil, France Jean-Claude Pairon

Susana Gomez-Olles, Barcelona Susana Gomez-Olles

Jaques Pralong, Jaques Pralong

Jacob Boe, Bergen Jacob Boe

Peter Reid, Western General Hospital, Edinburgh, Scotland Peter Reid

Orianne Dumas, Villejuif, France Orianne Dumas

Carl Reynolds, Royal Brompton Hospital Carl Reynolds

Jo Feary, Royal Brompton Hospital Jo Feary

Stephen Spiro, University College Hospital, London Stephen Spiro

Harriet Burge, Harriet Burge

Geraldine Burge, Birmingham Heartlands Hospital Geraldine Burge

Asilan Ilgaz, Ankara, Turkey Asilan Ilgaz

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Abstract

The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants (including in swimming pools) as irritants and sensitizers: how to evaluate types of bronchial reactions and reduce risks; (2) population-based studies of occupational obstructive diseases: use of databanks, advantages and pitfalls, what strategies to deal with biases and confounding?; (3) damp environments, dilapidated buildings, recycling processes, and molds, an increasing problem: mechanisms, how to assess causality and diagnosis; (4) diagnosis of occupational asthma and rhinitis: how useful are recombinant allergens (component-resolved diagnosis), metabolomics, and other new tests?; (5) how does exposure to gas, dust, and fumes enhance sensitization and asthma?; and (6) how to determine probability of occupational causality in chronic obstructive pulmonary disease: epidemiological and clinical, confirmation, and compensation aspects. A summary of the presentations and discussion is provided in this proceedings document. Increased knowledge has been gained in each topic over the past few years, but there remain aspects of controversy and uncertainty requiring further research.

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