Occupational Asthma Reference

Harries MG, Parkes PEG, Lessof ME, Orr TSC, Role of irritant receptors in asthma, Lancet, 1981;317:5-6,

Keywords: oa, sulphur dioxide, ch, as , tr

Known Authors

Maurice Lessof, Guys Hospital, London Maurice Lessof

Mark Harries, Brompton Hospital and Northwick Park Mark Harries

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Sulphur dioxide inhaled at low concentration had no delectable effect on forced expiratory volume in one second in non-asthmatic atopic controls, but it induced asthma and increased bronchial reactivity in nine symptomless atopic and non-atopic asthmatic patients. This increased reactivity was inhibited by sodium cromoglycate (SCG) and partly inhibited by atropine. This suggests that SCG, in addition to its ability to stabilise mast cells, may also act on bronchial irritant receptors or directly on smooth muscle in asthmatic patients

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