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Fatal lung disease in adults and children using humidifiers at home containing detergent biocides

Fatal lung disease in adults and children using humidifiers at home containing detergent biocides

A new interstitial lung disease has been described with unique histology showing bronchocentric acute lung injury which was temporally homogenious with subpleural and peripheral alveolar preservation. Specimens taken early in the disease showed obliterative bronchiolitis. Hyaline membranes and intra-alveolar fibroblastic pugs were frequent. There were no granuloma or honeycombing. BAL showed mostly normal lymphocytrs (0-18%), eosinophilia (0-61% mean 9%), neutrophils mean 9% (0-61%).

An outbreak os rapidly progressive respiratory disease in children and adults has been caused by biocides/detergents used in home humidifiers. Most were attributed to polyhexamethyleneguanidine. Removal of the detergent/biocide from humidifiers stopped the outbreak. Pregnant women were particularly susceptible.

References

Abstract Available for A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation Kim HJ, Lee M, Hong S, Huh JW, Do K, Jang SJ, Lim C, Chae EJ, Lee H, Jung M, Park Y, Park J, Kwon G, Gwack J, Youn S, Kwon J, Yang B, Jun B, Kim Y, Cheong H, Chun BC, Kim H, Lee K, Koh Y, A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation, Thorax, 2014;69:703-708,

Abstract Available for Humidifiers: the use of biocides and lung disease Pickering CAC, Humidifiers: the use of biocides and lung disease, Thorax, 2014;69:692-693,
Tony Pickering, Wythenshawe Hospital, Manchester, UK, an author of 'Humidifiers: the use of biocides and lung disease'

Abstract Available for A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome Hong S, Kim HJ, Huh JW, Do K, Jang SJ, Song JS, Choi S, Heo Y, Kim Y, Lim C, Chae EJ, Lee H, Jung M, Lee K, Lee M, Koh Y, A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome, Thorax, 69;694-702:,

Comments

Is there any links to cpap units with humidifiers in them
2/4/2015

some related to humidifiers
Abstract Available for A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation Kim HJ, Lee M, Hong S, Huh JW, Do K, Jang SJ, Lim C, Chae EJ, Lee H, Jung M, Park Y, Park J, Kwon G, Gwack J, Youn S, Kwon J, Yang B, Jun B, Kim Y, Cheong H, Chun BC, Kim H, Lee K, Koh Y, A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation, Thorax, 2014;69:703-708,

Full Text Available for Extrinsic allergic alveolitis caused by misting fountains Koschela D, Stark W, Karmann F, Sennekamp J, Müller-Wening D, Extrinsic allergic alveolitis caused by misting fountains, Respir Med, 2005;99:943-947,

Abstract Available for A case of hypersensitivity pneumonitis probably caused by a humidifier in winter [Japanese] Nakagawa A, Yamaguchi T, Takao T, Amano H, A case of hypersensitivity pneumonitis probably caused by a humidifier in winter [Japanese], Nippon Kyobu Shikkan Gakkai Zasshi, 1995;33:202-208,

Abstract Available for Hypersensitivity pneumonitis caused by a home humidifier [Review] [Japanese] Hagiwara S, Ishii Y, Sugiyama Y, Kitamura S, Hypersensitivity pneumonitis caused by a home humidifier [Review] [Japanese], Nippon Kyobu Shikkan Gakkai Zasshi, 1995;33:1024-1029,

Abstract Available for A case of hypersensitivity pneumonitis caused by a humidifier. Tsujino I, Betsuyaku T, Inaba S, Yoshikawa T, Terai T, A case of hypersensitivity pneumonitis caused by a humidifier., Nippon Kyobu Shikkan Gakkai Zasshi, 1992;30:1864-1868,

Abstract Available for Microbial contamination of ambient air by ultrasonic humidifier and preventive measures Oie S, Masumoto N, Hironaga K, Koshiro A, Kamiya A, Microbial contamination of ambient air by ultrasonic humidifier and preventive measures, Microbios, 1992;72:161-166,

Abstract Available for Humidifier syndrome as occupational disease in Switzerland. Jost M, Lehmann M, Humidifier syndrome as occupational disease in Switzerland., Schweiz Rundsch Med Prax, 1990;79:797-803,

Abstract Available for Extrinsic allergic alveolitis caused by a cold water humidifier Robertson AS, Burge PS, Wieland GA, Carmalt MH, Extrinsic allergic alveolitis caused by a cold water humidifier, Thorax, 1987;42:32-37,
Sherwood Burge, Oasys, an author of 'Extrinsic allergic alveolitis caused by a cold water humidifier' Alastair Robertson, Selly Oak Hospital, an author of 'Extrinsic allergic alveolitis caused by a cold water humidifier'

No Abstract Available for Hypersensitivity pneumonitis caused by home humidifier, a case report Matsumoto H, Nakano H, Fujikane T, Akaishi T, Sasaki N, Shimizu T, Onodera S, Hypersensitivity pneumonitis caused by home humidifier, a case report, Nippon Kyobu Shikkan Gakkai Zasshi, 1987;25:*-*,

No Abstract Available for A case of hypersensitivity pneumonitis caused by a humidifier Mikasa K, Mikami R, Sawaki M, Ito S, Katada H, Kasuga H, Shioya N, Narita N, A case of hypersensitivity pneumonitis caused by a humidifier, Nippon Kyobu Shikkan Gakkai Zasshi, 1986;24:1288-1291,

Full Text Available for Occupational asthma in a factory with a contaminated humidifier Burge PS, Finnegan M, Horsfield N, Emery D, Austwick P, Davies PS, Pickering CAC, Occupational asthma in a factory with a contaminated humidifier, Thorax, 1985;40:248-254,
Tony Pickering, Wythenshawe Hospital, Manchester, UK, an author of 'Occupational asthma in a factory with a contaminated humidifier' Sherwood Burge, Oasys, an author of 'Occupational asthma in a factory with a contaminated humidifier'

Full Text Available for An investigation of operating theatre staff exposed
to humidifier fever antigens COCKCROFT A, EDWARDS J, BEVAN C, CAMPBELL I, COLLINS G, HOUSTON K, JENKINS D, LATHAM S, SAUNDERS M, TROTMAN D, An investigation of operating theatre staff exposed to humidifier fever antigens, Br J Industr Med, 1981;38:144-151,

No Abstract Available for Humidifier-associated extrinsic allergic alveolitis van Assendelft A, Forsen KO, Keskinen H, Alanko K, Humidifier-associated extrinsic allergic alveolitis, Scand J Work Environ Health, 1979;5:35-41,

No Abstract Available for Hypersensitivity pneumonitis due to contamination of home humidifier Tourville DR, Weiss WI, Wertlake PT, Leudemann GM, Hypersensitivity pneumonitis due to contamination of home humidifier, J Allergy Clin Immunol, 1972;49:245-251,

No Abstract Available for Hypersensitivity pneumonitis related to a home furnace humidifier Sweet LC, Anderson JA, Callies QC, Coates EO, Hypersensitivity pneumonitis related to a home furnace humidifier, J Allergy Clin Immunol, 1971;48:171-178,

Abstract Available for A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome Hong S, Kim HJ, Huh JW, Do K, Jang SJ, Song JS, Choi S, Heo Y, Kim Y, Lim C, Chae EJ, Lee H, Jung M, Lee K, Lee M, Koh Y, A cluster of lung injury associated with home humidifier use: clinical, radiological and pathological description of a new syndrome, Thorax, 69;694-702:,

2/7/2015

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