What are the sensitivity and the specificity of specific IgE testing in the diagnosis of validated cases of occupational asthma?


** 2+ Both skin prick and serological tests are highly sensitive for detecting specific IgE and occupational asthma caused by most high molecular weight agents, but are not specific for diagnosing asthma.

Evidence

Baur X, Czuppon A , Diagnostic Validation Of Specific Ige Antibody Concentrations, Skin Prick Testing, And Challenge Tests In Chemical Workers With Symptoms Of Sensitivity To Different Anhydrides , J Allergy Clin Immunol , 1995 ; 96 : 489-494

PlattsMills TAE, Longbottom J, Edwards J, Cockcroft A, Wilkins S , Occupational asthma and rhinitis related to laboratory rats: serum IgG and IgE antibodies to the rat urinary allergen , J Allergy Clin Immunol , 1987 ; 79 : 505-515

Vandenplas O, Delwiche JP, Evrard G et al , Prevalence of occupational asthma due to latex among hospital personnel , Am J Respir Crit Care Med , 1995 ; 151 : 54-60


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