Reference

Grammer LC, Harris KE, Yarnold PR, Effect of respiratory protective devices on development of antibody and occupational asthma to an acid anhydride, Chest, 2002;121:1317-1322,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study aimed to determine whether the use of respiratory protective equipment would reduce the incidence of occupational asthma due to exposure to hexahydrophthalic anhydride (HHPA) in 66 newly hired individuals. Subjects were evaluated annually for development of positive antibody to HHPA and occupational, immunologic respiratory disease, including occupational asthma. With use of respiratory protective equipment, the rate of developing an occupational immunologic respiratory disease was reduced from approximately 10 to 2% per year. Occupational asthma developed in only three individuals, and they were all in the higher exposure category. Authors conclude that respiratory protective equipment can reduce the incidence of occupational immunologic respiratory disease, including occupational asthma, in employees exposed to HHPA.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

* 3 The use of respiratory protective equipment reduces the incidence of, but does not completely prevent, occupational asthma.

Non Bohrf Information

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