Reference

Grammer LC, Shaughnessy MA, Lowenthal M et al, Risk factors for immunologically mediated respiratory disease from hexahydrophthalic anhydride, J Occup Med, 1994;36:642-646,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study aimed to identify risk factors for development of immunologically mediated respiratory disease in workers exposed to hexahydrophthalic anhydride (HHPA). Of 57 employees in a workplace molding operation utilising HHPA, 7 had both IgE- and IgG-mediated disease, whereas 9 had only IgE-mediated disease. Although neither smoking, age, nor race were risk factors for development of immunologically mediated disease, exposure level and specific antibody were. Authors conclude that development of immunologically mediated respiratory disease due to HHPA is most closely associated with exposure level and development of specific IgE or IgG antibodies.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

Non Bohrf Information

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