Cathcart M, Nicholson P, Roberts D, Bazley M, Juniper C, Murray P, Randell M, Enzyme exposure, smoking and lung function in employees in the detergent industry over 20 years. Medical Subcommittee of the UK Soap and Detergent Industry Association, Occup Med (London), 1997;47:473-478,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Workers from five locations in the United Kingdom were subject to respiratory health surveillance including lung function testing over a period of 4-20 years. Exposure groups were defined by job history. Significantly different rates of fall in FEV1 and FVC with time were found by geographical location and by smoking habit, but there were no consistent trends with enzyme exposure between plants.

The following comments are from the editors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study shows correlation between airborne concentrations of enzyme and incidence of asthma in UK soap & detergent industry over 20 years

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

*** 2++ Reducing airborne exposure reduces the number of workers who become sensitised and who develop occupational asthma.

Non Bohrf Information

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