Butcher BT, Jones RN, O'Neil CE, Glindmeyer HW, Diem JE, Dharmarajan V, Weill H, Salvaggio JE, Longitudinal study of workers employed in the manufacture of toluene di-isocyanate, Am Rev Respir Dis, 1977;116:411-421,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Workers at a toluene-di-isocyanate (TDI) manufacturing plant were studied longitudinally to determine the effects of the chemical on their health. Workers reporting increased lower respiratory symptoms were from the non-smoker group. Immunologic studies showed development of positive skin test to a TDI-human serum albumin conjugate by some persons and an increasing incidence of TDI-specific IgE antibodies as measured by a RAST test. However, there was no correlation between positive TDI inhalation challenge and total IgE concentration or atopic status.

BOHRF Associated Evidence Statements

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