Reference

Burge PS, Non-specific bronchial hyper-reactivity in workers exposed to toluene di-isocyanate, diphenyl methane di-isocyanate and colophony, Eur J Respir Dis, 1982;63 Sup 123:91-96,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Histamine reactivity returned to normal more frequently in those who left work than in those who had moved within their original factories, suggesting that the latter had sufficient indirect exposure to maintain their symptoms and bronchial reactivity. Only 2/20 affected workers who had left factory were symptom free, and most had considerable reduction in quality of life by continuing asthma.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have no further exposure to the causative agent.

Redeployment to a low exposure area may lead to improvement or resolution of symptoms or prevent deterioration in some workers, but is not always effective.

Non Bohrf Information

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