Venables KM, Topping MD, Nunn AJ, Howe W, Newman Taylor AJ, Immunologic and functional consequences of chemical (tetrachlorophthalic anhydride)-induced asthma after four years of avoidance of exposure, J Allergy Clin Immunol, 1987;80:212-218,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Subjects were followed up and assessed 4.5 years after last exposure. 6 living patients reported continuing symptoms suggestive of asthma, and 5 who were studied in 1985 demonstrated mild bronchial hyper-responsiveness. All patients reported that they had improved since leaving the factory, but they still reported symptoms. Authors conclude that after avoidance of exposure to tetrachlorophthalic anhydride, concentrations of specific IgE fell and symptoms of asthma improved, however, both were still present 4 years later.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2+ The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

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