Valentino M, Pizzichini MA, Monaco F et al, Latex-induced asthma in four healthcare workers in a regional hospital, Occup Med (London), 1994;44:161-164,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

4 subjects were diagnosed as having latex hypersensitivity after skin prick-testing, and immunoglobulin E serum level against latex gave positive results (2 workers presented dermatitis as well as work-related respiratory symptoms, while the other 2 only showed symptoms suggesting occupational asthma). Changes in methacholine responsiveness also took place. In 1 case, an occupational exposure test resulted in a 24% drop in FEV1 value after 25 min of inhalation exposure. At least 1 year after diagnosis, 2 subjects who had been removed completely from latex exposure experienced no further latex-induced symptoms. The other workers, who continued working in the same laboratories using vinyl gloves, now display less severe symptoms but require regular anti-allergy treatment.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have no further exposure to the causative agent.

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