Pezzini A, Riviera A, Paggiaro PL, Spiazzi A, Gerosa F, Filieri M, Toma G, Tridente G, Specific IgE antibodies in twenty-eight workers with di-isocyanate-induced bronchial asthma, Clin Allergy, 1984;14:453-461,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

A specific IgE-mediated response was evaluated in 28 workers exposed to TDI or MDI, with diagnosis of occupational asthma and positive to bronchial provocative challenge. The presence of anti-di-isocyanate IgE was observed in 27% of subjects exposed to TDI and 83% of those exposed to MDI, particularly in individuals who experienced an acute massive exposure. An immediate-type response to bronchial provocative test was found in 66% of individuals with specific antibodies. Specific IgE are prevalent (91%) in subjects who developed symptoms before 6 years of exposure to isocyanates. The results suggest an association between the presence of specific IgE, early asthmatic symptoms and heavy episodic exposure.

BOHRF Associated Evidence Statements

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