BOHRF Original Authors' Main Conclusions
The original authors' main conclusions are taken from Abstract, Results and
Discussion. They are decided upon by the authors of the BOHRF occupational
asthma guidelines and form part of the guidelines.
Paper reports 9 cases of immediate type occupational asthma to reactive dyes in one dye industry. All patients had had asthmatic symptoms, 4 had had rhinitis and they had worked for 6 to 25 months. Skin prick tests with reactive dyes were positive and bronchoprovocation tests also produced immediate or dual types of bronchoconstriction. Radioallergosorbent test (RAST) technique with nitrocellulose filter paper as a solid phase was used to detect specific IgE to 4 reactive dye-human serum albumin conjugates. High specific IgE binding was found in 8 asthmatic workers compared with 13 negative controls. The RAST inhibition test revealed that there was no immunological cross-reactivity between 4 reactive dyes. These results suggested that the mechanism of their asthmatic symptoms was immunological, mostly an IgE-mediate reaction.
BOHRF Associated Evidence Statements
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with the following evidence statements
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