Lozewicz S, Assoufi BK, Hawkins R et al, Outcome of asthma induced by isocyanates, Br J Dis Chest, 1987;1:14-22,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

At 4-year follow-up, 82% of subjects continued to have respiratory symptoms and approximately half of these required treatment at least once a week, indicating a significant proportion of those with isocyanate-induced asthma are likely to have persisting symptoms for at least several years after exposure is avoided. FEV1 and FVC at follow-up were similar to values obtained at diagnosis.

The following comments are from the editors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Mean duration of symptomatic exposure was 2.7 years. No difference observed between those who were relocated within the factory and those who left the factory

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2+ The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

Non Bohrf Information

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