Reference

Agrup G, Belin L, Sjostedt L et al, Allergy to laboratory animals in laboratory technicians and animal keepers, Br J Ind Med, 1986;43:192-198,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Of 19 people with laboratory animal allergy symptoms and positive animal tests, 68% had a history of atopic dermatitis, rhinitis or asthma before they started work or reacted to one or more allergens in the standard battery. Atopic features were present in 3/11 (27%) people with animal related symptoms but with negative animal RAST and skin tests. Of the 30 with no animal related symptoms, 20% had a history of atopic disease or a positive reaction to a standard test or both. Atopy was commoner among those with positive tests to laboratory animal allergens. Smoking habits did not differ significantly.

The following comments are from the editors of the BOHRF occupational asthma guidelines and form part of the guidelines.

The first symptoms appeared after a mean latent period of 2.3 years.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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Atopy increases the risk of developing occupational asthma caused by exposure to many high molecular weight agents that induce the production of specific IgE antibodies.

Sensitisation and occupational asthma are most likely to develop in the first years of exposure for workers exposed to enzymes, complex platinum salts, isocyanates and laboratory animal allergens.

Non Bohrf Information

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