Occupational Asthma Reference

Gomez-Olles S, Madrid-San MF, Cruz MJ, Munoz X, Occupational asthma due to colistin in a pharmaceutical worker, Chest, 2010;137:1200-1201,

Keywords: Colistin, pharmacutical, new cause challenge, IgE negative, Spain, rhinitis, warehouseman, normal NSBR

Known Authors

Maria Jesus Cruz, Barcelona Maria Jesus Cruz

Xavier Munoz, Barcelona Xavier Munoz

Susana Gomez-Olles, Barcelona Susana Gomez-Olles

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To our knowledge, this is the first case report of a 24-year-old man working in a pharmaceutical company transporting and storing raw materials who developed occupational asthma (OA) to colistin. The specific inhalation challenge confirmed the diagnosis of OA to colistin. Specific IgE was not detected, because dot-blot analysis was negative at all colistin concentrations tested. To our knowledge, OA due to a peptide antibiotic has not previously been described. This antibiotic should be listed as a trigger of OA

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Agent Colistin
Job Pharmaceutical warehouseman
Specific IgE neg (dot/blot test)
Skin prick test not done
Non-specific reactivity normal (16mg/ml)
Serial Peak Flow not done
BAL not done
FENO not done
Basophil histamine release Not done
Specific Challenge positive immediate reaction

Follow-up relocated, no symptoms after 6 months


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