Occupational Asthma Reference

Nafees AA, Muneer MZ, Matteis SD, Amaral A, Burney P, Cullinan P, Impact of using different predictive equations on the prevalence of chronic byssinosis in textile workers in Pakistan, Occup Environ Med, 2022;79:242-244,http://dx.doi.org/10.1136/oemed-2021-107680

Keywords: Pakistan, lung function, predicted, byssinosis, FEV1

Known Authors

Paul Cullinan, Royal Brompton Hospital, London, UK Paul Cullinan

Peter Burney, Kings College, London Peter Burney

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.


Objective Byssinosis remains a significant problem among textile workers in low/middle-income countries. Here we share our experience of using different prediction equations for assessing ‘chronic’ byssinosis according to the standard WHO classification using measurements of forced expiratory volume in 1s (FEV1).

Methods We enrolled 1910 workers in a randomised controlled trial of an intervention to improve the health of textile workers in Pakistan. We included in analyses the 1724 (90%) men who performed pre-bronchodilator spirometry tests of acceptable quality. We compared four different equations for deriving lung function percentage predicted values among those with symptoms-based byssinosis: the third US National Health and Nutrition Examination Survey (NHANES-III, with ‘North Indian and Pakistani’ conversion factor); the Global Lung Function Initiative (GLI, ‘other or mixed ethnicities’); a recent equation derived from survey of a western Indian population; and one based on an older and smaller survey of Karachi residents.

Results 58 men (3.4%) had symptoms-based byssinosis according to WHO criteria. Of these, the proportions with a reduced FEV1 (<80% predicted) identified using NHANES and GLI; Indian and Pakistani reference equations were 40%, 41%, 14% and 12%, respectively. Much of this variation was eliminated when we substituted FEV1/forced vital capacity (FVC) ratio (less than lower limit of normality) as a measure of airway obstruction.

Conclusion Accurate measures of occupational disease frequency and distribution require approaches that are both standardised and meaningful. We should reconsider the WHO definition of ‘chronic’ byssinosis based on changes in FEV1, and instead use the FEV1/FVC.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference


The GLI predicted equations for spirometry do not apply to most of the population of South Asia due to substantial variance between different predicted equations. This poses a problem for diseases defined by spirometry, in this case stage 3 byssinosis. The authors show that using the unadjusted FEV1/FVC ratio can overcome this problem with a disease defined in terms of fixed airflow obstruction.

Please sign in or register to add your thoughts.

Oasys and occupational asthma smoke logo