Occupational Asthma Reference

Vandenplas O, Rifflart C, Evrard G, Thimpont J, Seed M, Agius R, Occupational asthma caused by an epoxy amine hardener, isophorone diamine (IPDA), Occup Med, 2017;67:722-724,https://doi.org/10.1093/occmed/kqx151

Keywords: OA, CR, Ch, belgium, epoxy, new cause, FeNO, NSBR, late reaction, concrete floor coater

Known Authors

Olivier Vandenplas, Universite Mont-Goginne, Yvoir Olivier Vandenplas

Raymond Agius, Centre for Occupational and Environmental Health, Manchester University Raymond Agius

Martin Seed, Manchester University Martin Seed

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We describe a 43-year-old epoxy floor layer who developed work-related asthma while exposed to an epoxy hardener based on isophorone diamine (IPDA). Challenge exposures to the curing of the epoxy resin system and subsequently to the polyfunctional amine hardener containing IPDA both elicited delayed asthmatic reactions. This report further indicates that exposure to epoxy hardeners containing polyfunctional amines should be considered as a potential cause of occupational asthma. Appropriate work hygiene measures should be implemented to minimize airborne exposure to these volatile compounds.

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