What are the sensitivity and the specificity of specific IgE testing in the diagnosis of validated cases of occupational asthma?

** 2+ Both skin prick and serological tests are sensitive for detecting specific IgE and occupational asthma caused by acid anhydrides and some reactive dyes; but have a lower specificity for diagnosing asthma.


Grammer L, Shaughnessy M, Kenamore B , Utility of antibody in identifying individuals who have or will develop anhydride-induced respiratory disease , Chest , 1998 ; 114 : 1199-1202

Howe W, Topping MD, Hawkins R, Newman Taylor AJ , Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody , J Allergy Clin Immunol , 1983 ; 71 : 5-11

Park HS, Kim YJ, Lee MK et al , Occupational asthma and IgE antibodies to reactive dyes , Yonsei Med J , 1989 ; 30 : 298-304

Park JW, Kim CW, Kim KS et al , Role of skin prick test and serological measurement of specific IgE in the diagnosis of occupational asthma resulting from exposure to vinyl sulphone reactive dyes , Occup Environ Med , 2001 ; 58 : 411-416

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