Park HS, Kim YJ, Lee MK et al, Occupational asthma and IgE antibodies to reactive dyes, Yonsei Med J, 1989;30:298-304,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Paper reports 9 cases of immediate type occupational asthma to reactive dyes in one dye industry. All patients had had asthmatic symptoms, 4 had had rhinitis and they had worked for 6 to 25 months. Skin prick tests with reactive dyes were positive and bronchoprovocation tests also produced immediate or dual types of bronchoconstriction. Radioallergosorbent test (RAST) technique with nitrocellulose filter paper as a solid phase was used to detect specific IgE to 4 reactive dye-human serum albumin conjugates. High specific IgE binding was found in 8 asthmatic workers compared with 13 negative controls. The RAST inhibition test revealed that there was no immunological cross-reactivity between 4 reactive dyes. These results suggested that the mechanism of their asthmatic symptoms was immunological, mostly an IgE-mediate reaction.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

** 2+ Both skin prick and serological tests are sensitive for detecting specific IgE and occupational asthma caused by acid anhydrides and some reactive dyes; but have a lower specificity for diagnosing asthma.

Non Bohrf Information

This page is showing the information from the BOHRF occupational asthma guidelines for this reference. To see additional information, including opinions left by users of this website please view the full reference. This page allows users to comment on the reference and suggest it as evidence for questions. These may be the existing questions from the Bohrf occupational asthma guidelines or questions that have been put forward by users of this website.

Oasys and occupational asthma smoke logo