Balboni A, Baricordi OR, Fabbri LM, Gandini E, Ciaccia A, Mapp CE, Association between toluene di-isocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57, Eur Respir J, 1996;9:207-210,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

The authors suggest genetic susceptibility for isocyanate occupational asthma, as evaluation of HLA class II gene products in toluene di-isocyanate-induced asthma cases showed a positive association with HLA-DQB1 * 0503 and a negative association with HLA-DQB1 * 0501 alleles, which differed at residue 57 for a single amino acid, i.e. aspartic acid in DQB1 * 0503 and valine in DQB1 * 0501.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

** 2- Genetic polymorphisms that code for human leukocyte antigen class II genes or respiratory anti-oxidant mechanisms may predispose to occupational asthma for a number of agents.

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