Occupational Asthma Reference

Bernstein DI, Kissling GE, Hershey GK, Yucesoy B, Johnson VJ, Cartier A, Gautrin D, Sastre J, Boulet L, Malo J, Quirce S, Tarlo SM, Langmeyer S, Luster MI, Lummus ZL, Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor a, J Allergy Clin Immunol, 2011;128:418-420,

Keywords: HDI, isocyanate, HLA, genetics

Known Authors

André Cartier, Hôpital de Sacré Coeur, Montreal, Quebec, Canada André Cartier

Joaquin Sastre, Fundacion Jimenez Diaz, Madrid Joaquin Sastre

Jean-Luc Malo, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Jean-Luc Malo

David Bernstein, Cincinatti David Bernstein

Denise Gautrin, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Denise Gautrin

Zana Lummus, Cincinatti Zana Lummus

Santiago Quirce, Madrid Santiago Quirce

Susan Tarlo, Toronto Susan Tarlo

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we have confirmed a previous observation in expanded groups of workers: a reported association between genotype combinations associated with Th2 and innate immunity and diisocyanate-induced asthma caused by HDI. Replication of these results in other background populations will be necessary to define the possible value of these genetic markers for risk assessment.

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