Occupational Asthma Reference

Lemiere C, Cartier A, Dolovich J, Malo JL, Isolated late asthmatic reaction after exposure to a high-molecular-weight occupational agent, subtilisin, Chest, 1996;110:823-824,

Keywords: Canada, subtilisin, late reaction, FEV1, IgE, canada, challenge, skin prick test, healthcare, case report

Known Authors

André Cartier, Hôpital de Sacré Coeur, Montreal, Quebec, Canada André Cartier

Jean-Luc Malo, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Jean-Luc Malo

Catherine Lemière, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Catherine Lemière

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High-molecular-weight agents generally induce immediate asthmatic reactions. We report the case of a subject who experienced a reaction that started after the first hour following exposure to subtilisin, a high-molecular-weight occupational agent. Any occurrence of immediate reaction was ruled out by measuring both FEV1 and lung volumes every 10 min in the first hour. This reaction was IgE-mediated as shown by immediate skin reactivity and increased specific IgE levels

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