Occupational Asthma Reference

Li G, Jiang J, Liao Y, Wan S, Yao Y, Luo Y, Chen X, Qian H, Dai X, Yin W, Min Z, Yi G, Tan X, Risk for lung-related diseases associated with welding fumes in an occupational population: Evidence from a Cox model., Front Public Health, 2022;10:990547,https://doi.org/10.3389/fpubh.2022.990547

Keywords: welder, china, lung cancer, chrome, air measurements

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Abstract

Background:
Welding fumes are a risk factor for welder pneumoconiosis. However, there is a lack of population information on the occurrence of welding fume-induced lung cancer, and little is known about the welding fume pathogenesis.

Methods:
Welding fume and metal ion concentrations were assessed in a vehicle factory in Wuhan. A Cox regression model estimated lung-related disease risk in workers by independent and combined factors.

Results:
Workers' exposures were divided into four grades; the highest exposure was among the welders in the maintenance workshop, the highest Mn and Fe exposure was 4 grades, and the highest Cr exposure was 3 grades. Subgroup analysis found that the risk of lung-related disease was 2.17 (95% CI: 1.31-3.57, p < 0.05) in welders compared with non-welders, and the risk of pulmonary disease in male welders was 2.24 (95% CI: 1.34-3.73, p < 0.05) compared to non-welders. Smoking welders had a 2.44 (95% CI: 1.32-4.51, p < 0.01) higher incidence of lung-related diseases than non-welders. Total years of work as an independent protective factor for lung-related disease risk was 0.72 (95% CI: 0.66-0.78, p < 0.01). As an independent risk factor, high-high and high-low exposure had a 5.39 (95% CI: 2.52-11.52, p < 0.001) and 2.17 (95% CI: 1.07-4.41, p < 0.05) higher risk for lung-related diseases, respectively.

Conclusions:
High welding fume exposure is a significant risk factor for lung-related disease in workers.

PMID: 36091502

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