Occupational Asthma Reference

Kaplan V, Baur X, Czuppon A, Ruegger M, Russi E, Speich R, Pulmonary hemorrhage due to inhalation of vapor containing pyromellitic dianhydride, Chest, 1993;104:644-645,

Keywords: ph, pyromellitic dianhydride, anhydride, epoxy resin, IgG, case report

Known Authors

Xaver Baur, Institute of occupational medicine, Hamburg Xaver Baur

Martin Ruegger, Martin Ruegger

Martin Ruegger, Luzern Martin Ruegger

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Pulmonary hemorrhage due to inhalation of fumes or powders containing trimellitic anhydride (TMA) is well known. We report pulmonary hemorrhage in a young man exposed to epoxy resin vapor containing pyromellitic dianhydride (PMDA). Serum IgG antibodies to PMDA could be detected. We conclude that the pulmonary hemorrhage was mediated by a reaction to PMDA in analogy to the TMA-induced disease. We suggest that exposure to any acid anhydride should be considered a possible cause of pulmonary hemorrhage since these compounds share structural and functional similarities

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