Occupational Asthma Reference
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Furusawa H, Peljto AL, Walts AD, Cardwell J, Molyneaux PL, Lee JS, Pérez ERF, Wolters PJ, Yang IV, Schwartz DA,
Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis,
Thorax,
2022;77:508-510,http://dx.doi.org/10.1136/thoraxjnl-2021-217693
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(Plain text:
Furusawa H, Peljto AL, Walts AD, Cardwell J, Molyneaux PL, Lee JS, Perez ERF, Wolters PJ, Yang IV, Schwartz DA,
Common idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis,
Thorax)
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Keywords: HP, fibrotic HP, genes, MUS5B, TERC, USA, IVD, DSP
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Abstract
A subset of patients with hypersensitivity pneumonitis (HP) develop lung fibrosis that is clinically similar to idiopathic pulmonary fibrosis (IPF). To address the aetiological determinants of fibrotic HP, we investigated whether the common IPF genetic risk variants were also relevant in study subjects with fibrotic HP. Our findings indicate that common genetic variants in TERC, DSP, MUC5B and IVD were significantly associated with fibrotic HP. These findings provide support for a shared etiology and pathogenesis between fibrotic HP and IPF.
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Comments
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This paper suggests that a patients genes, particularly MUC5B and those related to short telomers, are the underlying reason why some patients with hypersensitivity pneumonitis develop the fibrotic variant. It implies, although is not stated, that the genes are more important than cessation of exposure to the progression to fibrosis.
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