Occupational Asthma Reference

Jaakkola MS, Lajunen TK, Heibati B, Wang Y, Lai C, Jaakkola JJK, Occupation and subcategories of asthma: a population-based incident case–control study, Occup Environ Med, 2021;78:661-668,doi: 10.1136/oemed-2020-106953
(Plain text: Jaakkola MS, Lajunen TK, Heibati B, Wang Y, Lai C, Jaakkola JJK, Occupation and subcategories of asthma: a population-based incident case-control study, Occup Environ Med)

Keywords: OA, phenotype, IgE, non-atopic, fixed obstruction, Finland, ep

Known Authors

Maritta Jaakkola, Oulu University Finland Maritta Jaakkola

Jouni Jaakkola, Institute of Occupational and Environmental Medicine, Birmingham Jouni Jaakkola

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Background We hypothesised that occupational exposures differently affect subtypes of adult-onset asthma.

Objective We investigated potential relations between occupation and three subtypes of adult asthma, namely atopic asthma, non-atopic asthma and asthma–COPD overlap syndrome (ACOS).

Methods This is a population-based case–control study of incident asthma among working-age adults living in Pirkanmaa Hospital District in Southern Finland. The determinant of interest was occupation at the time of diagnosis of asthma or the job that the subject had quit due to respiratory symptoms. Asthma was divided into three mutually exclusive subtypes on the basis of any positive IgE antibody (atopic and non-atopic asthma) and presence of persistent airways obstruction in spirometry (ACOS). We applied unconditional logistic regression analysis to estimate adjusted OR (aOR), taking into account gender, age and smoking.

Results The following occupational groups showed significantly increased risk of atopic asthma: chemical industry workers (aOR 15.76, 95%?CI 2.64 to 94.12), bakers and food processors (aOR 4.69, 95%?CI 1.18 to 18.69), waiters (aOR 4.67, 95%?CI 1.40 to 15.56) and those unemployed (aOR 3.06, 95%?CI 1.52 to 6.17). The following occupations showed clearly increased risk of non-atopic asthma: metal workers (aOR 8.37, 95%?CI 3.77 to 18.59) and farmers and other agricultural workers (aOR 2.36, 95%?CI 1.10 to 5.06). Some occupational groups showed statistically significantly increased OR of ACOS: electrical and electronic production workers (aOR 30.6, 95%?CI 6.10 to 153.35), fur and leather workers (aOR 16.41, 95%?CI 1.25 to 215.85) and those retired (aOR 5.55, 95%?CI 1.63 to 18.97).

Conclusions Our results show that different occupations are associated with different subtypes of adult-onset asthma.

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