Is exposure to agents in the workplace a risk factor for developing occupational asthma?

The following references have been associated with this question by users of this website. They do not form part of the BOHRF occupational asthma guidelines.

burgeps Krop 2007 This paper provides evidence that occupational antigens can be carried into the home as well
Cedd Burge Robertson 2007 The prevalence of occupational asthma is significantly greater in work locations with greater exposure to aerosols of metal working fluid than in areas with lower levels of exposure to more contaminated fluids.
burgeps Maçãira 2007 Cross-sectional population survey of industrial cleaners in Sao Paulo, Brazil. Increasing odds ratio for new-onset occupational asthma with increasing years worked in full-time cleaning
burgeps Mirabelli 2007 New-onset asthma incidence from the ECHRS II study of healthcare workers between 1991 and 1998. Incidence increased in institution-based health-care providers (RR 2.3) and hospital technicians (RR 4.63). Little consistent effect of latex gloves. Incidence increased with use of cleaning products in spray form (RR2.36) and ammonia or bleach (RR 2.16).
burgeps Pronk 2007 Dose response with cumulative exposure demonstrated
burgeps Jacobs 2008
burgeps Rudbeck 2006 sensitisation after single large exposure to MDI
burgeps Pronk 2009 incidence increased in higher exposure group, particularly NSBR
burgeps Baatjies 2009 A history of large exposures with immediate respiratory symptoms increases risk of occupational asthma (OR 2.8) and work-related asthma without IgE (OR 5.8)
burgeps Brant 2009 clear dose response seen, no high dose tolerence
burgeps Sauni 2010 Longitudinal study of a cobalt refinery with cases defined by specific challenge. Increased incidence in high exposure areas, also odd ed effect of hydrogen fluoride and irritant gasses
burgeps Feary 2019
burgeps Wang 2019 This is a prospective questionnaire-based study which shows that adults (mean age 40) without asthma or rhinitis reporting dampness or mould odour at home or work are more likely to report doctor diagnosed asthma over the next 11 years than those not reporting dampness or mould odour at baseline. New onset doctor diagnosed asthma was reported in 4.3% and rhinitis symptoms in 26%. The adjusted odds ratio for doctor diagnosed asthma was 1.4 (95% CI 1.1-1.79) in those reporting dampness or mould in their workplace, 1.32 (95% CI 1.06–1.65) at home and 1.51 (95% CI 1.06–2.15) at both home and work. The mechanisms for the increased risks are not discussed.

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