Houba R, Heederik DJ, Doekes G, van Run PE, Exposure-sensitisation relationship for alpha-amylase allergens in the baking industry, Am J Respir Crit Care Med, 1996;154:130-136,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Workers were categorized according to job history and amylase exposure levels of their jobs. 25% had work-related symptoms, 9% had positive skin prick test to fungal amylase, 8% amylase-specific IgE. Atopy and amylase exposure appeared to be the most important determinants of skin sensitisation i.e.: prevalence ratio (PR) for atopy 20.8, medium exposure PR = 8.6 and high exposure PR = 15.9. For IgE sensitisation atopy was only significant determinant, PR = 8.3. A positive association was observed between positive skin prick and work-related symptoms. Overall authors conclude that a strong and positive relationship is shown between alpha-amylase allergen exposure levels and specific sensitisation in bakery workers.

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