Horne C, Quintana PJ, Keown PA et al, Distribution of DRB1 and DQB1 HLA class II alleles in occupational asthma due to western red cedar, Eur Respir J, 2000;15:911-914,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Patients with red cedar asthma had a higher frequency of HLA DQB1*0603 and DQB1*0302 alleles compared to a group of healthy exposed control subjects and a reduced frequency of DQB1*0501 allele. The frequency of the DRB1*0401-DQB1* 0302 haplotype was increased and the DRB1*0101-DQB1*0501 haplotype was reduced. Authors suggest that genetic factors such as human leukocyte antigen class II antigens may be associated with susceptibility or resistance to development of red cedar asthma.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

** 2- Genetic polymorphisms that code for human leukocyte antigen class II genes or respiratory anti-oxidant mechanisms may predispose to occupational asthma for a number of agents.

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