Heederik D, Houba R, An exploratory quantitative risk assessment for high molecular weight sensitizers: wheat flour, Ann Occup Hyg, 2001;45:175-185,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Exposure response modelling using classical epidemiological approaches and advanced statistical methods suggested an increased risk of sensitisation with increasing dust and allergen exposure and gave similar "lowest" or "no observed effect levels" (LOEL or NOEL) estimates. When sensitisation plus asthma or rhinitis was considered as critical endpoint, exposure-response relationships were steeper indicating lower LOEL values. (Atopics exposed to low levels of wheat allergen had approximately 2-fold increased risk of sensitisation compared with non-exposed atopics. This risk increased with increasing exposure, for atopics and non-atopics).

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

Non Bohrf Information

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