Grammer LC, Shaughnessy MA, Kenamore BD, Clinical and immunologic outcome of 42 individuals with trimellitic anhydride-induced immunologic lung disease after transfer to low exposure, Allergy Asthma Proc, 2000;21:355-359,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Employees with trimellitic anhydride-induced immunologic lung disease were studied after they had been moved to low-exposure jobs for more than 1 year. Pulmonary symptoms were obtained by physician-administered questionnaire, immunologic studies were performed using ELISA techniques and spirometry and chest films were obtained annually. Of 42, 36 were asymptomatic with normal spirometry. Only mild intermittent symptoms or mild abnormalities on spirometry were present in the other 6 individuals. Approximately half of the individuals had a decline in antibody titre.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

* 3 Redeployment to a low exposure area may lead to improvement or resolution of symptoms or prevent deterioration in some workers, but is not always effective.

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