Cullinan P, Cook A, Nieuwenhuijsen MJ et al, Allergen and dust exposure as determinants of work-related symptoms and sensitisation in a cohort of flour-exposed workers; A case-control analysis, Ann Occup Hyg, 2001;45:97-103,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study aimed to estimate the incidence of specific IgE sensitisation and allergic respiratory symptoms among UK bakery and flour mill workers and also to examine the roles of flour aeroallergen and total dust exposures in determining these outcomes. Incidence rates for work-related eye/nose and chest symptoms were 11.8 and 4.1 cases per 100 person years (py), respectively. Fewer employees developed positive skin prick tests to flour (2.2 cases per 100 py) or alpha-amylase (2.5 cases per 100 py). There were clear relationships between the risks of developing work-related symptoms or a positive skin prick test and three categories of estimated exposure to total dust or flour aeroallergen. Atopic employees were more likely to develop a positive skin prick test-but not work-related symptoms. These findings were unaffected by age, sex or cigarette smoking.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

Non Bohrf Information

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