Cullinan P, Harris JM, NewmanTaylor AJ et al, An Outbreak Of Asthma In A Modern Detergent Factory, Lancet, 2000;356:1899-1900,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Occupational and health information was collected by questionnaire from employees and 342 employees were given skin-prick tests. Results indicate a very high rate of enzyme-related sensitisation and asthma in the factory, leading to an estimate of 50 cases of occupational asthma in the current workforce, in addition to the six index cases. Enzyme sensitisation and work-related respiratory symptoms were positively correlated with airborne enzyme exposure. Authors conclude that enzyme encapsulation, the existing method of controlling occupational exposure to enzymes in the detergent industry, is insufficient by itself to prevent enzyme-induced allergy and asthma.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

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