Coutts IL, Lozewicz S, Dally MB, et al, Respiratory symptoms related to work in a factory manufacturing cimetidine tablets, Br Med J, 1984;288:1418,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

We issued a questionnaire and performed skin prick tests and spirometry on 3 groups of employees defined according to exposure. 13 (62%) of the 21 patients exposed daily, 4 (21%) of the 19 exposed more than once a week, and 3 (20%) of the 15 exposed less than once a week had work-related respiratory symptoms. Of 8 subjects with symptoms of the lower respiratory tract, 7 were in the group exposed most often. x2 testing for linear trend showed a strong relation between the proportion affected in each group and the frequency of exposure to dust (p < 0.001).

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

Non Bohrf Information

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