Burge PS, O'Brien IM, Harries MG, Peak flow rate records in the diagnosis of occupational asthma due to isocyanates, Thorax, 1979;34:317-323,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Peak expiratory flow rate (PEFR) was recorded in workers with respiratory symptoms who were exposed to isocyanate fumes at work. Each worker was also admitted for bronchial provocation testing to toluene di-isocyanate (TDI) or diphenylmethane di-isocyanate (MDI) fumes or both. A final assessment of work-related asthma made from subsequent work exposure was compared with the results of bronchial provocation testing and a subjective assessment of peak flow records. Both techniques were specific and sensitive. Recovery from work-induced asthma was shown to be slow - up to seventy days. Several workers developed a pattern resembling fixed airways obstruction.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

* 3 Pre to post shift changes in lung function cannot be recommended for the validation or exclusion of occupational asthma.

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