Wernfors M, Nielsen J, Schutz A et al, Phthalic anhydride-induced occupational asthma, Int Arch Allergy Appl Immunol, 1986;79:77-82,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Out of 118 workers exposed to phthalic anhydride (PA) dust for 2 months or more in 4 plants producing alkyd and/or polyunsaturated polyester resins, 28 suffered from work-related rhinitis, 13 from chronic productive bronchitis and 21 from work-associated asthma. Asthma was mostly of the late type and in 48% bronchial symptoms were preceded by rhinitis. Rhinitis was present in only 19% of non-asthmatics. 3 out of 11 asthmatics had a PA-positive skin test and in 2 subjects, antibodies were present. 4 out of 25 heavily exposed subjects without asthma had a non-specific bronchial hyperreactivity. Chronic productive bronchitis was common and was more prevalent among former workers than among present employees, indicating a selection of non-reacting subjects in the plant.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

** 2+ Occupational rhinitis and occupational asthma frequently occur as co-morbid conditions in IgE associated occupational asthma.

Non Bohrf Information

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