Venables KM, Topping MD, Howe W, Luczynska CM, Hawkins R, Newman Taylor AJ, Interaction of smoking and atopy in producing specific IgE antibody against a hapten protein conjugate, Br Med J, 1985;290:201-204,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Using a radioallergosorbent test with a tetrachlorophthalic anhydride (TCPA) human serum albumin conjugate, specific IgE antibody was detected in serum from 24 out of 300 factory floor workers exposed to TCPA. Of these 24, 20 (83.3%) were current smokers compared with 133 (48.2%) of 276 without antibody, and there was a weaker association with atopy, defined by skin tests with common allergens. Smoking and atopy interacted, the prevalence of antibody being 16.1% in atopic smokers, 11.7% in non-atopic smokers, 8.3% in atopic non-smokers, and nil in non-atopic non-smokers. Smoking may predispose to, and interact with atopy in, the production of specific IgE antibody to this hapten protein conjugate. Nasal symptoms were associated with work area but not with specific IgE against TCPA.

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