Valentino M, Rapisarda V, Course of isocyanate-induced asthma in relation to exposure cessation: Longitudinal study of 50 subjects, G Ital Med Lav Ergon, 2002;24:26-31,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Subjects followed for mean of 8.4 years. At follow-up, the group removed from exposure showed significant improvement in symptoms, consequent reduction in use of medications and increase in PD20 (9/37 subjects in this group were asymptomatic). By contrast, the condition of subjects who had remained exposed deteriorated significantly during follow-up in terms of symptoms, pulmonary function parameters, PD20 and the use of medication.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

*** 2++ The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have no further exposure to the causative agent.

Non Bohrf Information

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