Sjostedt L, Willers S, Orbaek P, Human leukocyte antigens in occupational allergy: a possible protective effect of HLA-B16 in laboratory animal allergy, Am J Ind Med, 1996;30:415-420,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Human leukocyte antigens and possible associations with occupational allergy to laboratory animals and atopy indicators were studied in 97 laboratory animal workers with airway symptoms and 27 symptom few workers, as well as in a population reference group of 123 blood donors in good health. 7 HLA antigens (HLA-A9, -B5, -B12, -B16, -DR4, -DR5, and -Drw6) suggested possible associations with symptoms and/or atopy indicators but only the HLA-B16 differences remained statistically significant. HLA-B16 was elevated in symptom-free subjects compared to the population reference group and in subjects with serum IgE < 10 kU/L. Subjects with serum IgE > 100 kU/L and sensitized against environmental and/or laboratory animals, including LAA asthmatics, lacked HLA-B16. Authors suggest that HLA-B16 or an immunosuppressive gene linked to HLA-B16 reduce the risk of producing IgE antibodies against animal protein allergens.

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